405878-87-7Relevant academic research and scientific papers
Optimization of CRF1R binding affinity of 2-(2,4,6- trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis
Zuev, Dmitry,Michne, Jodi A.,Pin, Sokhom S.,Zhang, Jie,Taber, Matthew T.,Dubowchik, Gene M.
, p. 431 - 434 (2005)
An efficient approach was developed to synthesize 2-(2,4,6- trichlorophenylamino)-4-trifluoromethyl-5-aminomethylthiazoles, corticotropin-releasing factor type 1 receptor (CRF1R) antagonists, by monoalkylation of amines with chloromethyl intermediate 5. The effect of variations in aminomethyl side chain of 6 on binding affinity is discussed. An efficient approach was developed to synthesize 2-(2,4,6-trichlorophenylamino)-4- trifluoromethyl-5-aminomethylthiazoles, corticotropin-releasing factor type 1 receptor (CRF1R) antagonists, by monoalkylation of amines with chloromethyl intermediate 5. The effect of variations in aminomethyl side chain of 6 on binding affinity is discussed.
