405911-17-3

Basic information

• Product Name: GW 3965 HYDROCHLORIDE
• Synonyms: 3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;GW3965 HCl;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride;GW3965 hydrochloride, >=98%;Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride;GW3965 HCl Salt
• CAS NO: 405911-17-3
• Molecular Formula: C33H31ClF3NO3.HCl
• Molecular Weight: 618.51300
• Product Categories: Inhibitors
• Mol File: 405911-17-3.mol
• Article Data: 0

Chemical Properties

• Appearance: white/
• Solubility: DMSO: ≥20mg/mL
• CAS DataBase Reference: GW 3965 HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GW 3965 HYDROCHLORIDE(405911-17-3)
• EPA Substance Registry System: GW 3965 HYDROCHLORIDE(405911-17-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 405911-17-3(Hazardous Substances Data)

Usage

Uses

GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.

Biochem/physiol Actions

GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.