40594-98-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 1H-1,2,3-triazole-5-carboxylate is used as a key intermediate in the synthesis of potent inhibitors of bacterial β-lactamase. These inhibitors play a crucial role in the development of new antibiotics, as they help to overcome bacterial resistance to existing treatments. By targeting and inhibiting β-lactamase enzymes, these compounds can restore the effectiveness of β-lactam antibiotics, which are commonly used to treat a wide range of bacterial infections.

InChI:InChI=1/C5H7N3O2/c1-2-10-5(9)4-3-6-8-7-4/h3H,2H2,1H3,(H,6,7,8)

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 87051-40-9 butyl β-methylaminoacrylate 

Downstream Products

• 53897-99-7 1H-1,2,3-triazole-4-carboxamide 
• 24650-17-7 1H-[1,2,3]triazole-4-carboxylic acid hydrazide 
• 91348-65-1 ethyl 2-(4-bromophenyl)-2H-1,2,3-triazole-4-carboxylate 
• 1312297-99-6 ethyl 1-tosyl-1H-1,2,3-triazole-4-carboxylate 
• 1312297-96-3 C₂₃H₂₅NO₄S 
• 1312297-94-1 C₂₃H₂₅NO₄S 
• 1253113-49-3 ethyl 2-[(2-iodophenyl)methyl]-2H-1,2,3-triazole-4-carboxylate 
• 1253113-44-8 ethyl 2-((5-chloro-2-[(phenylmethyl)oxy]phenyl)methyl)-2H-1,2,3-triazole-4-carboxylate 
• 1253113-46-0 N-(2,6-difluorophenyl)-1H-1,2,3-triazole-4-carboxamide 
• 916082-08-1 (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-[2-(4-ethoxycarbonyl-2H-1,2,3-triazol-2-yl)ethylidene]piperidine 
• 916083-98-2 (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-[2-(5-ethoxycarbonyl-1H-1,2,3-triazol-1-yl)ethylidene]piperidine 
• 916083-97-1 (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-[2-(4-ethoxycarbonyl-1H-1,2,3-triazol-1-yl)ethylidene]piperidine 
• 139029-47-3 ethyl 2-benzyl-2H-1,2,3-triazole-4-carboxylate 
• 126800-24-6 ethyl 1-(benzyl)-1H-1,2,3-triazole-4-carboxylate 

Relevant academic research and scientific papers

Catalyst-free one-pot, four-component approach for the synthesis of di- And tri-substituted: N -sulfonyl formamidines

A straightforward one-pot, multicomponent approach was developed to synthesize di- and tri-substituted N-sulfonyl formamidines from sulfonyl chlorides, NaN3, ethyl propiolate, and primary/secondary amines under mild conditions without catalysts or additives. Structural analysis of the di-substituted sulfonyl formamidines indicated formation of the E-syn/anti isomeric form. Tri-substituted analogues only formed E-isomers.