406-05-3Relevant academic research and scientific papers
Reformatsky Reaction of Methyl 2-Bromo-3,3,3-trifluoropropanoate. A Synthetic Method for α-Trifluoromethyl-β-hydroxy Esters
Yokozawa, Tsutomu,Ishikawa, Nobuo,Nakai, Takeshi
, p. 1971 - 1974 (2007/10/02)
The Reformatsky reagent, prepared from the title bromo-ester and zinc powder in dioxane, is found to be thermally stable enough to undergo addition reactions with aldehydes to afford the α-trifluoromethyl-β-hydroxy esters in high yields.The unique reactiv
(TRIFLUOROMETHYL)KETENE SILYL ACETAL AS AN EQUIVALENT TO THE TRIFLUOROPROPIONIC ESTER ENOLATE: PREPARATION AND ALDOL-TYPE REACTIONS WITH ACETALS
Yokozawa, Tsutomu,Nakai, Takeshi,Ishikawa, Nobuo
, p. 3987 - 3990 (2007/10/02)
The title reagent, readily prepared from methyl β,β,β-trifluoropropionate with trimethylsilyl triflate, is shown to react with a broad variety of acetals to provide the corresponding α-CF3 β-alkoxy esters in good yields.
