406-05-3Relevant articles and documents
Reformatsky Reaction of Methyl 2-Bromo-3,3,3-trifluoropropanoate. A Synthetic Method for α-Trifluoromethyl-β-hydroxy Esters
Yokozawa, Tsutomu,Ishikawa, Nobuo,Nakai, Takeshi
, p. 1971 - 1974 (2007/10/02)
The Reformatsky reagent, prepared from the title bromo-ester and zinc powder in dioxane, is found to be thermally stable enough to undergo addition reactions with aldehydes to afford the α-trifluoromethyl-β-hydroxy esters in high yields.The unique reactiv