406-99-5 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(2,2-DIFLUORO-PROPYLAMINO)-ETHANOL is used as a building block and intermediate for the synthesis of pharmaceuticals and other organic compounds. Its unique structure allows it to be incorporated into the design of new drugs, potentially enhancing their efficacy and selectivity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(2,2-DIFLUORO-PROPYLAMINO)-ETHANOL is used as a key component in the development of novel therapeutic agents. Its presence in a molecule can influence the pharmacokinetic and pharmacodynamic properties of the drug, making it a valuable tool for researchers in drug discovery.
Used in Chemical Synthesis:
2-(2,2-DIFLUORO-PROPYLAMINO)-ETHANOL is utilized as a versatile reagent in chemical synthesis, enabling the creation of a wide range of organic compounds. Its difluoropropylamino group can participate in various chemical reactions, facilitating the synthesis of complex molecules with specific properties.
Used in Drug Development:
In the realm of drug development, 2-(2,2-DIFLUORO-PROPYLAMINO)-ETHANOL is employed as a precursor in the production of innovative pharmaceuticals. Its unique chemical characteristics can contribute to the discovery of new drugs with improved therapeutic profiles and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 406-99-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 406-99:
(5*4)+(4*0)+(3*6)+(2*9)+(1*9)=65
65 % 10 = 5
So 406-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H11F2NO/c1-5(6,7)4-8-2-3-9/h8-9H,2-4H2,1H3
406-99-5Relevant academic research and scientific papers
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)- 6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity
Dow, Robert L.,Carpino, Philip A.,Hadcock, John R.,Black, Shawn C.,Iredale, Philip A.,DaSilva-Jardine, Paul,Schneider, Steven R.,Paight, Ernest S.,Griffith, David A.,Scott, Dennis O.,O'Connor, Rebecca E.,Nduaka, Chudy I.
supporting information; experimental part, p. 2652 - 2655 (2010/03/03)
We report the design, synthesis, and structure-activity relationships of novel bicyclic lactam-based cannabinoid type 1 (CB1) receptor antagonists. Members of these series are potent, selective antagonists in in vitro/in vivo efficacy models of CB1 antagonism and exhibit robust oral activity in rodent models of food intake. These efforts led to the identification of 19d, which has been advanced to human clinical trials for weight management.
Process for Preparing Bicyclic Pyrazolyl
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Page/Page column 14, (2010/11/28)
A process for preparing compounds of Formula (I) is described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of disease linked to the mediation of the cannabinoid receptors in animals.
Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
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Page/Page column 31, (2010/02/11)
Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals.
