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• 529-19-1 2-Methylbenzonitrile 

Relevant academic research and scientific papers

An Intramolecular Cycloaddition Approach to the Kauranoid Family of Diterpene Metabolites

Synthetic studies toward the ent-kauranoid family of diterpene natural products are reported. An intramolecular (4 + 3) cycloaddition allows the direct elaboration of diverse natural product frameworks, encompassing a challenging bicyclo[3.2.1]octane core. The established routes comprise only a few synthetic operations (3-5 steps), transforming a range of simple starting materials into the tetracyclic scaffolds that are commonly found in many ent-kaurene metabolites.

Synthesis of 2-Acetylbenzonitriles and Their Reactivity in Tandem Reactions with Carbon and Hetero Nucleophiles: Easy Access to 3,3-Disubstituted Isoindolinones

2-Acetylbenzonitriles have been conveniently synthesized by the oxidation of the respective 2-ethylbenzonitriles, combining in a one-pot procedure radical bromination and hydrolysis reactions. The obtained ketones reacted under very mild conditions with c

Incorporation of Carbon Dioxide into Carbamate Directing Groups: Palladium-Catalyzed meta-C–H Olefination and Acetoxylation of Aniline Derivatives

Carbon dioxide (CO2), a readily available, non-toxic, and inexpensive greenhouse gas, is an ideal reagent for carbamate synthesis. For the first time, CO2 has been efficiently incorporated into a novel nitrile-containing directing group (DG) for meta-C–H activation of anilines under mild conditions. Thus, various aniline derivatives were meta-olefinated with palladium(II) acetate. meta-C–H acetoxylation was also feasible and the carbamate DG could be easily removed under basic conditions. The practicality of substrate preparation, functional group tolerance, and versatility of this method make it a valuable addition to the meta-C–H functionalization of anilines. (Figure presented.).

Synthesis of 2-Substituted 3-Alkylidene-2,3-dihydro-1H-isoindol-1-imines through cyclization of [1-(2-Cyanophenyl)alkylidene]aminide intermediates generated from the reaction of 2-(1-Azidoalkyl)benzonitriles with NaH

A convenient sequence for the preparation of 3-alkylidene-2,3-dihydro-1H-isoindol-1-imine derivatives 6 has been developed. Thus, 2-(1-azidoalkyl)benzonitriles 2, readily accessible from 2- Alkylbenzonitriles, are allowed to react with NaH in DMF at 0 to

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Protoberberins from Reissert Compounds VI [1]. Diastereoselective Synthesis and Relative Configuration of 2-Benzoyl-1-cyano-1-(1-phenylalkyl)-1,2-dihydroisoquinolines

The alkylation of Reissert compounds 8 by sec-benzyl bromides 4, 7, and 10 diastereoselectively affords the title compounds 11 and 12. X-Ray structure analysis confirms an opposite configuration of the chiral centers in 11 and 12. The benzyl bromides 4, 7, and 10 are prepared by standard procedures.