406196-97-2

Upstream product

• 406196-96-1 2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol 
• 406196-93-8 4-(3-chlorophenyl)-N,2-dimethoxy-N-methyl-6-quinazolinecarboxamide 
• 406196-94-9 2-chloro-4-(3-chlorophenyl)-N-methoxy-N-methyl-6-quinazolinecarboxamide 
• 406196-95-0 [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](1-methyl-1H-imidazol-5-yl)methanone 

Relevant academic research and scientific papers

Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series

Based on the structure of R115777 (tipifarnib, Zarnestra), a series of farnesyltransferase inhibitors have been synthesized by modification of the 2-quinolinone motif and transposition of the 4-chlorophenyl ring to the imidazole or its replacem