406205-74-1 Usage
Description
BAY 59-3074 is a novel cannabinoid CB1/CB2 receptor partial agonist, which possesses antihyperalgesic and antiallodynic effects. It is a compound that interacts with the cannabinoid receptors in the body, providing potential therapeutic benefits for various conditions.
Uses
Used in Pharmaceutical Industry:
BAY 59-3074 is used as a therapeutic agent for managing pain, particularly in conditions where there is an increased sensitivity to pain or discomfort. Its antihyperalgesic and antiallodynic effects make it a promising candidate for the treatment of chronic pain and neuropathic pain.
Used in Pain Management:
BAY 59-3074 is used as a pain-relieving agent to alleviate symptoms associated with various conditions, such as arthritis, fibromyalgia, and other chronic pain disorders. Its interaction with cannabinoid receptors helps to reduce pain perception and improve the quality of life for patients suffering from these conditions.
Used in Neuropathic Pain Treatment:
BAY 59-3074 is used as a treatment option for neuropathic pain, which is caused by damage or dysfunction of the nervous system. Its agonistic effects on CB1/CB2 receptors can help to reduce the pain signals transmitted by the nervous system, providing relief for patients with conditions like diabetic neuropathy, post-herpetic neuralgia, and other neuropathic pain disorders.
Biological Activity
Novel CB 1 /CB 2 receptor partial agonist (K i values are 48.3 and 45.5 nM at human CB 1 and CB 2 receptors respectively). Orally active CB 1 agonist in vivo . Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.
Check Digit Verification of cas no
The CAS Registry Mumber 406205-74-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,2,0 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 406205-74:
(8*4)+(7*0)+(6*6)+(5*2)+(4*0)+(3*5)+(2*7)+(1*4)=111
111 % 10 = 1
So 406205-74-1 is a valid CAS Registry Number.
InChI:InChI=1/C18H13F6NO4S/c19-17(20,21)8-3-9-30(26,27)29-13-5-1-4-12(10-13)28-16-7-2-6-15(14(16)11-25)18(22,23)24/h1-2,4-7,10H,3,8-9H2
406205-74-1Relevant articles and documents
A catalytic fluoride-rebound mechanism for C(sp3)-CF3 bond formation
Levin, Mark D.,Chen, Tiffany Q.,Neubig, Megan E.,Hong, Cynthia M.,Theulier, Cyril A.,Kobylianskii, Ilia J.,Janabi, Mustafa,O'Neil, James P.,Toste, F. Dean
, p. 1272 - 1275 (2017/06/30)
The biological properties of trifluoromethyl compounds have led to their ubiquity in pharmaceuticals, yet their chemical properties have made their preparation a substantial challenge, necessitating innovative chemical solutions. We report the serendipitous discovery of a borane-catalyzed formal C(sp3)-CF3 reductive elimination from Au(III) that accesses these compounds by a distinct mechanism proceeding via fluoride abstraction, migratory insertion, and C-F reductive elimination to achieve a net C-C bond construction. The parent bis(trifluoromethyl)Au(III) complexes tolerate a surprising breadth of synthetic protocols, enabling the synthesis of complex organic derivatives without cleavage of the Au-C bond. This feature, combined with the fluoride-rebound mechanism, was translated into a protocol for the synthesis of 18F-radiolabeled aliphatic CF3-containing compounds, enabling the preparation of potential tracers for use in positron emission tomography.
