406215-61-0

Basic information

• Product Name: 1,2-dimethoxy-4-(2-tert-butyldimethylsiloxyethyl)benzene
• Synonyms: 1,2-dimethoxy-4-(2-tert-butyldimethylsiloxyethyl)benzene
• CAS NO: 406215-61-0
• Molecular Weight: 296.482
• Mol File: 406215-61-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-dimethoxy-4-(2-tert-butyldimethylsiloxyethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethoxy-4-(2-tert-butyldimethylsiloxyethyl)benzene(406215-61-0)
• EPA Substance Registry System: 1,2-dimethoxy-4-(2-tert-butyldimethylsiloxyethyl)benzene(406215-61-0)

Safety Data

• Hazardous Substances Data: 406215-61-0(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 

Downstream Products

• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 523-02-4 (S)-(-)-norcoralydine 
• 406215-71-2 4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide 
• 406215-59-6 Toluene-4-sulfonic acid 2-[2-((S)-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-4,5-dimethoxy-phenyl]-ethyl ester 
• 406215-57-4 (S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 406215-56-3 (S)-(-)-2-[2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol 
• 406215-55-2 (S)-(-)-2-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-3-yl)-4,5-dimethoxyphenyl]ethanol 
• 406215-63-2 4,5-dimethoxy-2-(2-tert-butyldimethylsiloxyethyl)benzaldehyde 
• 406215-62-1 1-bromo-4,5-dimethoxy-2-(2-tert-butyldimethylsiloxyethyl)benzene 

Relevant articles and documents

Harnessing open-source technology for low-cost automation in synthesis: Flow chemical deprotection of silyl ethers using a homemade autosampling system

An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-liquid extraction step was used to provide effective inline purification. A Raspberry Pi single-board computer was employed to interface with the motors used in the autosampler and actuated fluidic valves.

Asymmetric synthesis of the protoberberine alkaloid (s)-(-)-xylopinine using enantiopure sulfinimines

A concise enantioselective synthesis of (S)-(-)-xylopinine (1) is described involving the addition of the laterally lithiated derivative of o-tolunitrile of 16 to enantiopure sulfinimine (+)-14. Treatment of the resulting cyano sulfinamide adduct (-)-17b with DIBAL-H accomplishes five operations in a single pot and furnishes the cyclic imine (+)-18 in good yield. Reduction and cyclization affords (S)-(-)-1. Alternatively basic hydrolysis of 17b,c gives isoquinolone 21 that is cyclized and reduced to give (S)-(-)-1.