40626-39-9Relevant academic research and scientific papers
Oxidation of isosafrole by sodium hypochlorite catalysed by manganese porphyrins: Unusual competition between epoxidation and O-dealkylation
Chiavetto, Luisella Bocchio,Guglielmetti, Gianfranco,Querci, Cecilia,Ricci, Marco
, p. 1091 - 1094 (1996)
Isosafrole (1a) and isoeugenol methyl ether (1b), two closely related substrates, behave very differently when subjected to manganese porphyrins catalysed epoxidation by sodium hypochlorite. A possible explanation is given, in terms of an unusual competition between the epoxidation and the O-dealkylation of the -OCH2O-moiety.
Formal [3+2] cycloaddition reactions of electron-rich aryl epoxides with alkenes under Lewis acid catalysis affording tetrasubstituted tetrahydrofurans
Macías-Villamizar, Víctor E.,Cuca-Suárez, Luís,Rodríguez, Santiago,González, Florenci V.
supporting information, (2020/02/18)
We report on the regio- and stereoselective synthesis of tetrahydrofurans by reaction between epoxides and alkenes in the presence of a Lewis acid. This is an unprecedented formal [3+2] cycloaddition reaction between an epoxide and an alkene. The chemical reaction represents a very concise synthesis of tetrahydrofurans from accessible starting compounds.
Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines
Bolli, Martin H.,Ley, Steven V.
, p. 2243 - 2246 (2007/10/03)
An efficient combinatorial access to β-hydroxyamines suitable for automation is achieved by the mild oxidation of alcohols to aldehydes by polymer supported perruthenate (PSP), the subsequent clean olefination of the obtained aldehydes by polymer supported Wittig reagents followed by the epoxidation of the olefins by dimethyldioxirane (DMDO), and the final aminolysis of the epoxides with various amines is described.
Troponoids. 7. Chemistry and Dopamine Agonist Activity of Ciladopa and Related Aralkyltroponylpiperazines
Bagli, Jehan,Bogri, T.,Voith, Katherine,Lee, D.
, p. 186 - 193 (2007/10/02)
A series of N-aralkyltroponylpiperazine derivatives were synthesized and evaluated for dopaminergic activity in rats rendered hypokinetic by the bilateral injection of 6-hydroxydopamine (6-OHDA) into the anterolateral hypothalamus.Several members of the series were active, and a structure-activity relationship is presented.A few selected compounds were also evaluated with regard to their ability to induce contralateral rotational behavior in rats with a unilateral 6-OHDA-induced lesion of the nigrostriatal dopamine (DA) pathway and to suppress elevated serum prolactin levels.The compounds were compared to bromocriptine.Some of the more potent analogues were also assayed for their binding affinity to dopamine (DA) and α1-adrenergic receptors.The results (a) established that the potency of some of the compounds were comparable or superior to that of bromocriptine, (b) indicated that potent dopaminergic activity was dependent on the presence of both a substituted phenyl and a troponylpiperazine moiety, and (c) confirmed that the dopaminergic activity depends on relative and absolute stereochemistry.
