40632-21-1

Basic information

• Product Name: URIDINE-5,6-D2
• Synonyms: URIDINE-5,6-D2;1--D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione-d2;1--D-Ribofuranosyluracil-d2;NSC 20256-d2;Uridin-d2;-Uridine-d2
• CAS NO: 40632-21-1
• Molecular Formula: C9H10D2N2O6
• Molecular Weight: 246.21
• Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Isotope Labeled Compounds;Nucleotides;Isotope Labelled Compounds
• Mol File: 40632-21-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 162-164°C
• Appearance: /
• Density: 1.689g/cm³
• Refractive Index: 1.643
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: URIDINE-5,6-D2(CAS DataBase Reference)
• NIST Chemistry Reference: URIDINE-5,6-D2(40632-21-1)
• EPA Substance Registry System: URIDINE-5,6-D2(40632-21-1)

Safety Data

• Hazardous Substances Data: 40632-21-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Labelled Uridine, a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA).

InChI:InChI=1/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6+,7?,8-/m1/s1/i1D,2D

Upstream product

• 58-96-8 uridine 

Relevant articles and documents

Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide

We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D 2O media. Georg Thieme Verlag Stuttgart.

METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING

The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.