406476-99-1Relevant academic research and scientific papers
Cu/TEMPO catalyzed dehydrogenative 1,3-dipolar cycloaddition in the synthesis of spirooxindoles as potential antidiabetic agents
Babu, Spoorthy N.,Daniel, J. Arul,Devi, S. Asha,Nawaz Khan, Fazlur Rahman,Noor, Ayesha,Teja, Chitrala
, p. 12262 - 12271 (2020)
A series of spiro-[indoline-3,3′-pyrrolizin/pyrrolidin]-2-ones, 4, 5 and 6 were synthesized in a sequential manner from Cu-TEMPO catalyzed dehydrogenation of alkylated ketones, 1 followed by 1,3-dipolar cycloaddition of azomethine ylides via decarboxylative condensation of isatin, 2 and l-proline/sarcosine, 3 in high regioselectivities and yields. The detailed mechanistic studies were performed to identify the reaction intermediates, which revealed that the reaction proceeds via dehydrogenative cycloaddition. Additionally, the regio and stereochemistry of the synthesized derivatives were affirmed by 2D NMR spectroscopic studies. The synthesized derivatives were explored further with molecular docking, in vitro antioxidant, and anti-diabetic activities.
Synthesis of a new series of quinolinyl chalcones as anticancer and antiinflammatory agents
Kotra, Vijay,Ganapaty,Adapa, Srinivas R.
experimental part, p. 1109 - 1116 (2010/11/02)
A new series of quinolinyl chalcone derivatives (SGCH 1-20) have been synthesized by the reaction of quinolinyl and chloroquinolinyl acetophenones with substituted aromatic aldehydes. These compounds have been characterized by IR, 'H NMR, mass spectral an
