406478-97-5

Upstream product

• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 406478-96-4 (R)-2-allyl-5-oxopyrrolidine-2-carboxylic acid 

Downstream Products

• 406479-01-4 N^α-[(5R,8RS)-8-tert-butyldimethylsilyloxy-2,6-dioxo-1-azaspiro[4.4]octyl]-L-phenylalanyl-L-prolinamide 
• 406478-99-7 N^α-[(5R,8RS)-8-tert-butyldimethylsilyloxy-2,6-dioxo-1-azaspiro[4.4]octyl]-L-phenylalanine benzyl ester 
• 406479-02-5 (S)-1-[(S)-2-((R)-2,6-Dioxo-1,7-diaza-spiro[4.4]non-8-en-7-yl)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid amide 
• 406478-98-6 N^α-[(5R,8RS)-8-hydroxy-2,6-dioxo-1-azaspiro[4.4]octyl]-L-phenylalanine benzyl ester 

Relevant academic research and scientific papers

Conformationally restricted TRH analogues: Constraining the pyroglutamate region

A modified synthetic route has been developed so that the steric size of constraints added to the pyroglutamate region of TRH (pGluHisProNH2) can be varied. Both an analogue with a smaller ethylene bridge and a larger, more flexible propane bri