406496-43-3Relevant academic research and scientific papers
N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors
Jia, Zhaozhong J.,Su, Ting,Zuckett, Jingmei F.,Wu, Yanhong,Goldman, Erick A.,Li, Wenhao,Zhang, Penglie,Clizbe, Lane A.,Song, Yonghong,Bauer, Shawn M.,Huang, Wenrong,Woolfrey, John,Sinha, Uma,Arfsten, Ann E.,Hutchaleelaha, Athiwat,Hollenbach, Stanley J.,Lambing, Joseph L.,Scarborough, Robert M.,Zhu, Bing-Yan
, p. 2073 - 2078 (2007/10/03)
A class of N,N-dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)- benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines has been discovered as potent factor Xa inhibitors with desirable in vitro and in vivo anticoagulant activity
Substituted oxoazaheterocyclyl compounds
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Page/Page column 94, (2008/06/13)
This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..
Piperazin-2-one amides as inhibitors of factor xa
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, (2008/06/13)
Novel piperazin-2-one containing compounds of general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa arc described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
