406502-75-8

Upstream product

• 6346-15-2 dimethyl α-chloromethylphosphonate 
• 158109-77-4 (S,E)-N-(4-methoxybenzylidene)-4-methylbenzenesulfinamide 

Downstream Products

• 406502-82-7 dimethyl (2S)-(-)-3-(p-methoxyphenyl)-2H-azirine 2-phosphonate 
• 406502-81-6 dimethyl (2R)-(+)-2-(p-methoxyphenyl)-2H-azirine 3-phosphonate 
• 406502-86-1 dimethyl (2R,6S,7R)-(-)-[7-(4-methoxy-phenyl)-2-methyl-1-aza-bicyclo-[4.1.0]hept-3-en-6-yl] phosphonate 
• 406502-85-0 dimethyl (6S,7R)-(-)-[7-phenyl-3,4-dimethyl-1-aza-bicyclo[4.1.0]hept-3-en-6-yl] phosphonate 
• 406502-92-9 dimethyl (2R,6S,7R)-(-)-[7-(4-methoxyphenyl)-2-methyl-1-aza-bicyclo[4.1.0]hept-6-yl] phosphonate 
• 406502-93-0 dimethyl (2S,6R)-(+)-[2-(p-methoxybenzyl)-6-methylpiperidin-2-yl]phosphoate 
• 406502-84-9 dimethyl (6S,7R)-(-)-[7-(4-methoxyphenyl)-3,4-dimethyl-1-aza-bicyclo[4.1.0]-hept-3-en-6-yl]-phosphonate 
• 406502-79-2 dimethyl (2S,3R)-(-)-3-(p-methoxyphenyl)aziridine-2-phosphonate 
• 406502-77-0 dimethyl (S_s,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-(p-methoxyphenyl)aziridine-2-phosphonate 

Relevant academic research and scientific papers

Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of α-amino phosphonates

An aza-Darzens reaction, involving the addition of chloromethylphosphonate anions to enantiopure sulfinimines, has been developed for the asymmetric synthesis of aziridine 2-phosphonates. Best results involve cyclization of the syn and anti diastereomeric

2H-Azirine 3-phosphonates: a new class of chiral iminodienophiles. Asymmetric synthesis of quaternary piperidine phosphonates.

[reaction: see text] Diels-Alder reactions of enantiomerically enriched 2H-azirine 3-phosphonates and dienes stereoselectively furnish optically pure, bicyclic aziridine adducts that on hydrogenation afford the first examples of enantiopure quaternary pip