40657-18-9Relevant academic research and scientific papers
Convenient synthesis of long alkyl-chain triazolylglycosides using ionic liquid as dual promoter-solvent: Readily access to non-ionic triazolylglycoside surfactants for evaluation of cytotoxic activity
Ketsomboon, Nutthanicha,Saeeng, Rungnapha,Srisook, Klaokwan,Sirion, Uthaiwan
, (2021/08/26)
A convenient method for the one-pot synthesis of long alkyl-chain triazolylglycosides using ionic liquid as dual promoter and solvent is described via a sequential one-pot two-step glycosidation-CuAAc click reaction. The reaction was carried out using commercially available substrates, including glycosyl bromides, sodium azide and various long alkyl-chain alkynes to achieve the corresponding products in moderate to high yields. Furthermore, this approach was successfully applied for the preparation of non-ionic monocatenary triazolylglycoside surfactants in excellent yields through simple deacetylation. Subsequently, these surfactants were further evaluated for their cytotoxic activity.
Triazole glycolipid derivatives and coordination of that the use of bacteria
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Paragraph 0027; 0032-0034, (2017/09/01)
The invention relates to a kind of triazole glycolipid derivatives and application thereof to synergically resist drug-resistant bacteria. The triazole derivatives containing a monosaccharide group are compounds shown as a formula I, or pharmaceutically acceptable salts. The provided triazole derivatives have synergic bacteriostatic effect for conventional antibiotics, help to substantially reduce usage amount of antibiotics when being combined with the conventional antibiotics for usage, and provide an approach for reasonable safe usage of antibiotics. In the formula I, R1 is an acetyl-protected or non-acetyl-protected monosaccharide group, R2 is a C6-C18 linear or branched alkyl, and n is an integer of 1-4.
Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins
Sahoo, Laxminarayan,Singhamahapatra, Anadi,Loganathan, Duraikkannu
, p. 2615 - 2625 (2014/04/17)
A series of novel haloglycolipids were synthesized based on Cu(i) catalyzed Huisgen's [3 + 2] cycloaddition reaction of diversely functionalized azides and alkynes, using a mixture of N-bromosuccinimide and Cu(i) halide as the halogen source. Since halogen atoms, like bromine and iodine, with a very high scattering power facilitate the solving of crystal structures, the title haloglycolipids could prove to be invaluable in structure-based drug design involving membrane proteins as targets. This journal is the Partner Organisations 2014.
Formation of conjugated polynaphthalene via Bergman cyclization
Miao, Changcheng,Zhi, Jian,Sun, Shiyuan,Yang, Xi,Hu, Aiguo
experimental part, p. 2187 - 2193 (2011/04/15)
A series of enediyne containing chiral phthalimides were synthesized through Sonogashira coupling reactions. These enediynes were then subjected to thermal Bergman cyclization under vacuum. Polynaphthalenes with pendant chiral groups were obtained and characterized using GPC, IR spectroscopy, NMR spectroscopy, UV-Vis spectroscopy, and photoluminescence analysis. Under properly optimized conditions, the chirality of chiral directing group was maintained according to CD spectra of final products. After removal of chiral directing groups, weak CD signals representative of main chain chirality were visible. Further modification of the structure of the enediyne compounds will facilitate the synthesis of chiral polynaphthalene through this rather simple way. Extension of the Bergman cyclization to polymer chemistry is promising in the construction of novel polymers with rigid polyarene back-bones.
