40662-45-1 Usage
Uses
Used in Organic Synthesis:
2-Hydroxy-2-methyl-d3-propionic-3,3,3-d3 Acid is used as a synthetic building block for the development of various organic compounds. The presence of deuterium atoms in the molecule makes it a valuable tool in the synthesis of isotopically labeled compounds, which can be used in research and development for understanding reaction mechanisms, studying metabolic pathways, and developing new pharmaceuticals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Hydroxy-2-methyl-d3-propionic-3,3,3-d3 Acid is used as a starting material for the synthesis of isotopically labeled drug candidates. These labeled compounds can help researchers study the pharmacokinetics, pharmacodynamics, and metabolic profiles of potential drugs, leading to the development of more effective and safer medications.
Used in Chemical Analysis:
2-Hydroxy-2-methyl-d3-propionic-3,3,3-d3 Acid can also be employed in chemical analysis as an internal standard or a reference compound. The incorporation of deuterium atoms allows for the differentiation between the labeled compound and other similar molecules, enabling accurate quantification and identification in various analytical techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
Used in Material Science:
In the field of material science, 2-Hydroxy-2-methyl-d3-propionic-3,3,3-d3 Acid can be utilized in the synthesis of isotopically labeled polymers and other advanced materials. These materials can be used to study the effects of isotopic substitution on the properties of the materials, such as their mechanical strength, thermal stability, and chemical reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 40662-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,6 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 40662-45:
(7*4)+(6*0)+(5*6)+(4*6)+(3*2)+(2*4)+(1*5)=101
101 % 10 = 1
So 40662-45-1 is a valid CAS Registry Number.
40662-45-1Relevant academic research and scientific papers
The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors
Bergare, Jonas,Kingston, Lee,Guly, Dominic J.,Dolan, James,Lewis, Richard J.,Elmore, Charles S.
, p. 434 - 441 (2020/07/13)
As part of a medicinal chemistry program aimed at developing a leukotriene C4 synthase inhibitor for the treatment of asthma, two tritium-labeled and one stable isotope-labeled compounds were required. The synthesis of the tritium-labeled compounds used a standard bromination-tritiodehalogentation approach. One of the tritium-labeled compounds was observed to exchange its tritium label slowly with the solvent. The stable isotope-labeled compound was prepared in seven steps (3percent overall yield) from [2H6]acetone in a modification of the route used by medicinal chemistry.
Synthesis of flutamide-d7 and its main metabolite-d6
Passarella,Martinelli,Passarotti,Valenti
, p. 275 - 279 (2007/10/03)
With the main objective of examining the pharmacokinetics of flutamide, flutamide-d7 and its main metabolite-d6 have been prepared. By carboxylation of Grignard-derivative (IV), deuterocarboxylic acid (V) was prepared from which acyl
