40663-92-1Relevant academic research and scientific papers
A one-pot, three-step synthesis of α-aminophosphonic acids
Ryabukhin, Sergey V.,Panov, Dmitriy M.,Shivanyuk, Alexander N.,Plaskon, Andrey S.,Zarudnitskiy, Evgeniy N.,Lukin, Oleg
, p. 2079 - 2084 (2014)
A total of 20 α-aminophosphonic acids are synthesized in 73-89% yields via a one-pot, three-step procedure involving chlorotrimethylsilane- promoted condensation of carbonyl compounds and primary amines yielding azomethine intermediates, subsequent reaction with tris(trimethylsilyl) phosphite to give the corresponding trimethylsilylphosphonic esters and finally, mild cleavage with methanol-water. The wide scope and simple set-up and work-up procedures of the reported method allow the synthesis of a diverse set of α-aminophosphonic acids possessing two different functional groups. Georg Thieme Verlag Stuttgart, New York.
