406676-08-2

Upstream product

• 406676-05-9 (S)-4-chloro-1,1-diethoxy-3-(tert-butyldimethylsilyloxyl)butane 
• 259138-08-4 (S)-1,1-diethoxy-3,4-epoxybutane 
• 69178-10-5 2-styryl-1,3-dithiane 
• 14371-10-9 (E)-3-phenylpropenal 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 406676-07-1 (S)-4,4-diethoxy-1-(2-styryl-[1,3]dithian-2-yl)butan-2-ol 

Downstream Products

• 406676-10-6 (5R,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-8-[2-((E)-styryl)-[1,3]dithian-2-yl]-octanoic acid ethyl ester 
• 406676-59-3 (5S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-8-[2-((E)-styryl)-[1,3]dithian-2-yl]-octanoic acid ethyl ester 
• 406676-45-7 (5S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3,5-dihydroxy-8-[2-((E)-styryl)-[1,3]dithian-2-yl]-octanoic acid ethyl ester 
• 406676-57-1 (5R,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3,5-dihydroxy-8-[2-((E)-styryl)-[1,3]dithian-2-yl]-octanoic acid ethyl ester 
• 406676-52-6 (S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 406676-60-6 (R)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one 
• 406676-53-7 (S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one 
• 406676-61-7 (R)-6-[(E)-(S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-oxo-6-phenyl-hex-5-enyl]-5,6-dihydro-pyran-2-one 
• 406676-55-9 (S)-6-[(E)-(S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-oxo-6-phenyl-hex-5-enyl]-5,6-dihydro-pyran-2-one 
• 406676-09-3 (3S)-(tert-butyldimethylsilyloxyl)-4-(2-styryl-[1,3]dithian-2-yl)-butyraldehyde 

Relevant academic research and scientific papers

Stereoselective synthesis of kurzilactone and determination of its absolute configuration

Both (5S,7S)- and (5R,7S)-isomers of kurzilactone were synthesized from a 'chiral epoxy-aldehyde synthon' through the coupling of an acyl anion equivalent and the dianion of acetoacetate, followed by formation of the Kawa-type lactone by cyclization and elimination. Comparing the spectral data of the synthesized and naturally occurring kurzilactone, the C(5)- and C(7)-stereogenic centers of the natural kurzilactone was assigned a corrected anti-relationship with (5R,7S)-absolute configuration.