406676-26-4 Usage
Description
5-Chloro-2,3-difluoro-4-iodopyridine is a pyridine derivative with the molecular formula C5HClF2IN, featuring chlorine, fluorine, and iodine atoms. It is a valuable intermediate in organic chemistry due to its unique structure and functional groups.
Uses
Used in Pharmaceutical Industry:
5-Chloro-2,3-difluoro-4-iodopyridine is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of biologically active compounds.
Used in Agrochemical Industry:
5-Chloro-2,3-difluoro-4-iodopyridine is also utilized as a precursor in the production of agrochemicals, playing a role in the creation of substances that can protect crops and enhance agricultural productivity.
Used in Materials Science:
5-Chloro-2,3-difluoro-4-iodopyridine is employed in the synthesis of new materials, where its chemical properties and reactivity are leveraged to produce innovative and useful materials.
Used in Research and Development:
Due to its versatility in chemical reactions, 5-Chloro-2,3-difluoro-4-iodopyridine is a key compound in research and development, aiding scientists in exploring new chemical pathways and syntheses.
Check Digit Verification of cas no
The CAS Registry Mumber 406676-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,6,7 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 406676-26:
(8*4)+(7*0)+(6*6)+(5*6)+(4*7)+(3*6)+(2*2)+(1*6)=154
154 % 10 = 4
So 406676-26-4 is a valid CAS Registry Number.
406676-26-4Relevant articles and documents
Regiochemical flexibility: The optional functionalization of 2,3,5-trihalopyridines at the 4- or 6-position
Bobbio, Carla,Schlosser, Manfred
, p. 4533 - 4536 (2007/10/03)
A deprotonation study was performed using 2,3,5-trichloropyridine, 3,5-dichloro-2-fluoropyridine and 5-chloro-2,3-difluoropyridine as the substrates. Upon reaction with lithium diisopropylamide (LDA), deprotonation occurred exclusively at the 4-position. Subsequent carboxylation and iodination led to the acids 1 and 4-iodopyridines 2. The exposure of the latter compounds to lithium 2,2,6,6-tetramethylpiperidide (LITMP) caused deprotonation and immediately ensuing iodine migration. The intermediates were trapped with dry ice to afford the carboxylic acids 3. Upon neutralization, the 6-iodopyridines 4 were obtained. These compounds readily exchanged the heavy halogen for metal when treated with isopropylmagnesium chloride. In this way, functional groups could be selectively introduced in the 6-position. Employing carbon dioxide routinely as the model electrophile, trihalopyridinecarboxylic acids were formed which, all unknown so far, should provide valuable new building blocks for pharmaceutical research. Moreover, the selective nucleophilic displacement of the halogen at the 2-position could give rise to an immense variety of new structures.
