406679-31-0Relevant academic research and scientific papers
Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase
Rückle, Thomas,Biamonte, Marco,Grippi-Vallotton, Tania,Arkinstall, Steve,Cambet, Yves,Camps, Montserrat,Chabert, Christian,Church, Dennis J.,Halazy, Serge,Jiang, Xuliang,Martinou, Isabelle,Nichols, Anthony,Sauer, Wolfgang,Gotteland, Jean-Pierre
, p. 6921 - 6934 (2007/10/03)
Several lines of evidence support the hypothesis that c-Jun N-terminal kinases (JNKs) play a critical role in a wide range of disease states including cell death (apoptosis)-related and inflammatory disorders (epilepsy, brain, heart and renal ischemia, ne
Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases
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Page 14, (2008/06/13)
The present invention is related to sulfonamide derivatives having a lipophilic moiety and which are substantially soluble under physiological conditions. Said compounds are notably for use as pharmaceutically active compounds. The present invention also
