406680-79-3Relevant academic research and scientific papers
Copper-Promoted O-Arylation of the Phenol Side Chain of Tyrosine Using Triarylbismuthines
Gagnon, Alexandre,Hébert, Martin,Le Roch, Adrien
, p. 5363 - 5367 (2020)
A general method for the O-arylation of the side chain of tyrosine using triarylbismuth reagents is reported. The reaction is mediated by copper diacetate, operates at 50 °C under oxygen in dichloromethane in the presence of pyridine, shows excellent functional group compatibility, and retains the integrity of the stereogenic center. The protocol was used to arylate the tyrosine residue of dipeptides and tripeptides.
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors
Pan, Huili,Yang, Kanghui,Zhang, Jian,Xu, Yingying,Jiang, Yuqi,Yuan, Yumei,Zhang, Xiaopan,Xu, Wenfang
, p. 717 - 726 (2013/07/26)
Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the surface of different tumour cells. Based on our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we designed and synthesized L-isoserine tripeptide derivatives as APN inhibitors. Among these compounds, one compound 16l (IC50=2.51±0.2 M) showed similar inhibitory effect compared with control compound Bestatin (IC50=6.25±0.4 M) and it could be used as novel lead compound for the APN inhibitors development as anticancer agents in the future.
Helical pores self-assembled from homochiral dendritic dipeptides based on L-Tyr and nonpolar α-amino acids
Percec, Virgil,Dulcey, Andres E.,Peterca, Mihai,Adelman, Peter,Samant, Ritika,Balagurusamy, Venkatachalapathy S. K.,Heiney, Paul A.
, p. 5992 - 6002 (2008/02/04)
The synthesis of dendritic dipeptides (4-3,4-3,5)12G2-CH 2-Boc-L-Tyr-X-OMe where X = Gly, L-Val, L-Leu, L-lle, L-Phe, and L-Pro is reported. Their self-assembly in bulk and in solution and the structural and retrostructural analysis of their pe
Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases
Mak, Chi Ching,Brik, Ashraf,Lerner, Danica L.,Elder, John H.,Morris, Garrett M.,Olson, Arthur J.,Wong, Chi-Huey
, p. 2025 - 2040 (2007/10/03)
Based on the substrate transition state and our strategy to tackle the problem of drug resistance, a series of HIV/FIV protease (HIV/FIV PR) monocyclic inhibitors incorporating a 15- or 17-membered macrocycle with an equivalent P3 or P3′ group and a uniqu
