406683-69-0

Usage

Uses

Used in Pharmaceutical Industry:
Fmoc Aeg-O-Ally HCl is used as a reagent in solid-phase peptide synthesis for the selective coupling of the Aeg-O-Ally residue with other amino acid building blocks. Its Fmoc group can be easily removed under mild acidic conditions, facilitating the synthesis of complex peptides with tailored properties for drug development and therapeutic applications.
Used in Biochemistry Research:
In the field of biochemistry, Fmoc Aeg-O-Ally HCl is employed as a key component in the synthesis of peptides with specific structural requirements. This allows researchers to explore the properties and functions of these peptides, contributing to a deeper understanding of biological processes and the development of novel bioactive compounds.

Upstream product

• 107-18-6 allyl alcohol 
• 172405-45-7 N-[2'-(N'-(9-fluorenylmethyloxycarbonyl)-amino)ethyl]glycine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 169396-89-8 tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate 

Downstream Products

• 1028077-23-7 allyl N-[2-((fluorenylmethoxycarbonyl)amino)ethyl]-N-[(N²,N²-bis(tert-butoxycarbonyl)-O⁶-benzylguanin-9-yl)acetyl]glycinate 

Relevant academic research and scientific papers

Synthesis method of N-Fmoc (fluorenylmethoxycarbonyl) ethylenediamine propylene acetate hydrochloride

The invention discloses a synthesis method of N-Fmoc (fluorenylmethoxycarbonyl) ethylenediamine propylene acetate hydrochloride. Particularly, chloroacetic acid, ethylenediamine, allyl alcohol, THF (tetrahydrofuran), Fmoc-osu, N-methylmorpholine, ethyl acetate, isopropyl alcohol and methyl tert-butyl ether are taken as raw materials and subjected to an ammonization reaction, a salification reaction, an esterification reaction and an Fmoc protection reaction. The synthesis method of N-Fmoc (fluorenylmethoxycarbonyl) ethylenediamine propylene acetate hydrochloride is high in yield, low in cost,high in product purity and suitable for industrialization and facilitates aftertreatment.

A convenient route to N-[2-(Fmoc)aminoethyl]glycine esters and PNA oligomerization using a bis-N-Boc nucleobase protecting group strategy

(Chemical Equation Presented) A simple and practical synthesis of the benzyl, allyl, and 4-nitrobenzyl esters of N-[2-(Fmoc)aminoethyl]glycine is described starting from the known N-(2-aminoethyl)glycine. These esters are stored as stable hydrochloride salts and were used in the synthesis of peptide nucleic acid monomers possessing bis-N-Boc-protected nucleobase moieties on the exocyclic amino groups of ethyl cytosin-1-ylacetate, ethyl adenin-9-ylacetate and ethyl (O6-benzylguanin-9-yl)acetate. Upon ester hydrolysis, the corresponding nucleobase acetic acids were coupled to N-[2-(Fmoc)aminoethyl] glycine benzyl ester or to N-[2-(Fmoc)aminoethyl]glycine allyl ester in order to retain the O6 benzyl ether protecting group of guanine. The Fmoc/bis-N-Boc-protected monomers were successfully used in the Fmoc-mediated solid-phase peptide synthesis of mixed sequence 10-mer PNA oligomers and are shown to be a viable alternative to the currently most widely used Fmoc/Bhoc-protected peptide nucleic acid monomers.

Convergent strategies for the attachment of fluorescing reporter groups to peptide nucleic acids in solution and on solid phase

The site-selective conjugation of peptide nucleic acids (PNA) with fluorescent reporter groups is essential for the construction of hybridisation probes that can report the presence of a particular DNA sequence. This paper describes convergent methods for