406684-84-2Relevant academic research and scientific papers
Synthesis of fused pyridopyrrolidine dione derivatives using hetero Diels-Alder reactions
Mason, Helen J.,Wu, Ximao,Schmitt, Rebecca,Macor, John E.,Yu, Guixue
, p. 8931 - 8934 (2001)
Hetero Diels-Alder reactions of heteroaromatic amidines and maleimide afforded novel fused pyridopyrrolidine dione scaffolds in moderate to good yields under mild conditions.
Microwave-assisted synthesis and structure-activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives
Nascimento-Junior, Nailton M.,Mendes, Thaiana C.F.,Leal, Daniella M.,Correa, Claudia Maria N.,Sudo, Roberto T.,Zapata-Sudo, Gisele,Barreiro, Eliezer J.,Fraga, Carlos A.M.
supporting information; experimental part, p. 74 - 77 (2010/03/30)
We described herein the optimization of the synthetic methodology exploited to obtain the pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine sedative prototype 1a and novel analogues designed by successive molecular simplifications. By applying microwave irradiation during the hetero Diels-Alder key-step to obtain the heterotricyclic scaffold, under solvent-free conditions, we were able to obtain the desired compounds in drastically shorter times and better yields. Additionally, in vivo evaluation of the sedative effects of these heterocyclic derivatives showed that 1a and the novel structurally-related analogue 1e were the most efficient compounds to impair the locomotor activity in mice at the dose of 10 μmol/kg.
