406687-58-9Relevant articles and documents
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
Wood, Jill,Bagi, Cedo M.,Akuche, Christiana,Bacchiocchi, Antonietta,Baryza, Jeremy,Blue, Marie-Luise,Brennan, Catherine,Campbell, Ann-Marie,Choi, Soongyu,Cook, James H.,Conrad, Patricia,Dixon, Brian R.,Ehrlich, Paul P.,Gane, Todd,Gunn, David,Joe, Ted,Johnson, Jeffrey S.,Jordan, Jerold,Kramss, Richard,Liu, Peiying,Levy, Joan,Lowe, Derek B.,McAlexander, Ian,Natero, Reina,Redman, Aniko M.,Scott, William J.,Town, Christopher,Wang, Ming,Wang, Yamin,Zhang, Zhonghua
, p. 4965 - 4968 (2007/10/03)
A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.
