406726-77-0

Basic information

• Product Name: N-[4-(1H-indol-3-yl)butanoyl]-L-tryptophan
• CAS NO: 406726-77-0
• Molecular Formula: C₂₃H₂₃N₃O₃
• Molecular Weight: 389.447
• Mol File: 406726-77-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 765.3°C at 760 mmHg
• Flash Point: 416.6°C
• Density: 1.336g/cm³
• Vapor Pressure: 1.26E-24mmHg at 25°C
• Refractive Index: 1.704
• CAS DataBase Reference: N-[4-(1H-indol-3-yl)butanoyl]-L-tryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(1H-indol-3-yl)butanoyl]-L-tryptophan(406726-77-0)
• EPA Substance Registry System: N-[4-(1H-indol-3-yl)butanoyl]-L-tryptophan(406726-77-0)

Safety Data

• Hazardous Substances Data: 406726-77-0(Hazardous Substances Data)

Upstream product

• 406726-76-9 4-(1H-Indol-3-yl)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester 

Relevant articles and documents

Carbamic acid compounds comprising an amide linkage as hdac inhibitors

This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the formula (1) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: —NR1C(═O)—and —C(═O)NR1—; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.