40673-66-3

Upstream product

• 121-89-1 3-Nitroacetophenone 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 34744-36-0 2-[(3-{1-[(4,5-Diphenyl-oxazol-2-yl)-hydrazono]-ethyl}-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol 
• 1449713-91-0 C₁₉H₁₈Cl₂FNO 
• 1449713-92-1 C₁₉H₁₉Cl₂NO 
• 1449713-93-2 C₁₉H₁₈Cl₃NO 
• 1449713-94-3 C₁₉H₁₈Cl₂FNO 
• 1449713-95-4 C₁₉H₁₈Cl₃NO 
• 1449713-96-5 C₂₁H₂₄Cl₂N₂O 
• 40673-74-3 [N,N-bis(2-chloroxyethyl)-3-amino]acetophenone 
• 1449713-86-3 C₂₃H₂₆Cl₄N₂O 
• 1449713-87-4 C₁₉H₁₇Cl₄NO 
• 1449713-88-5 C₁₉H₁₈Cl₂N₂O₃ 
• 1449713-89-6 C₁₉H₁₈BrCl₂NO 
• 1449713-90-9 C₂₀H₂₁Cl₂NO₂ 
• 40673-71-0 N,N-bis[2-(tosyloxyethyl)-3-amino]acetophenone 

Relevant academic research and scientific papers

Synthesis of novel macrolides-linked chalcone derivatives and recognition ability toward Cu2+

A series of novel macrolides-linked chalcone derivatives 2a-c and 3a-d were synthesized from compounds 1a-d with 1,2-benzenedicarbonyl chloride. Their structures were confirmed by IR, 1H NMR, and high resolution mass spectrometry. The crystal s

Synthesis and antimicrobial activity of novel chalcone derivatives

A series of novel 3-[N, N-bis(2-hydroxyethyl)-amino]-chalcone derivatives 3a-3j were synthesized by the aldol condensation of [N, N-bis(2-hydroethyl)-3- amino]-acetophenone 2 with aromatic aldehydes. Their structures were further confirmed by ESI-HRMS, 1H NMR, IR and elemental analysis. X-ray analysis reveals crystal 3b is a monoclinic system with P21/n space group. The antimicrobial activities of the newly synthesized chalcones in vitro were evaluated and the results indicated that most compounds presented moderate to good antimicrobial activities, especially the antifungal capability. Compounds 3a, 3d, 3f and 3g revealed obvious potency against Candida albicans with MIC values of 32 μg/mL, which were better compared with others.

Synthesis and antitumor activity of novel nitrogen mustard-linked chalcones

A series of nitrogen mustard-linked chalcones were synthesized and evaluated for their antitumor activity in vitro against the K562 and HepG2 cell lines. The aldol condensation of [N,N-bis(chloroethyl)-3-amino]-acetophenone (2) with aromatic aldehydes afforded the nitrogen mustard-linked chalcones. Among the analogs tested, compounds 5e and 5k exhibited significant anti-proliferation activities against K562 cells with IC50 values of 2.55 and 0.61 μM, respectively, which revealed higher cell toxicity than the standard drugs cisplatin (IC50 > 200 μM) and adriamycin (IC50 = 14.88 μM). The methoxyl and N,N-dimethyl groups on the B-ring of the chalcone frame enhanced the inhibitory activities against both the K562 and HepG2 cell lines. The structure-activity relationship study indicated that the inhibitory activities significantly varied with the position(s) and species of the substituted group(s). A series of nitrogen mustard-linked chalcones were prepared and evaluated for their antitumor activities against the K562 and HepG2 cell lines. The structure-activity relationship study indicated that the methoxyl and N,N-dimethyl groups on the B-ring of the chalcone frame may enhance the inhibitory activities of the chalcones. Copyright