40679-37-6Relevant academic research and scientific papers
Method for synthesizing 2, 4, 6-trisubstituted 1, 3, 5-triazine compound from aromatic aldehyde and ammonium iodide
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Paragraph 0109-0112, (2020/08/06)
The invention discloses a method for synthesizing a 2, 4, 6-trisubstituted 1, 3, 5-triazine compound from aromatic aldehyde and ammonium iodide, and belongs to the field of organic synthesis. According to the method, aromatic aldehyde and ammonium iodide undergo a one-pot reaction under the catalytic action of a ferric salt, so that the 2, 4, 6-trisubstituted 1, 3, 5-triazine compound is obtained.According to the present invention, the small molecule aryl aldehyde raw material and the iron salt catalyst are used, such that the cost is low, the reaction conditions are mild, the symmetric 2, 4,6-trisubstituted 1, 3, 5-triazine compound can be highly selectively obtained, and the brand-new synthesis idea is provided for the triazine ring construction.
Atom-efficient synthesis of 2,4,6-trisubstituted 1,3,5-triazinesviaFe-catalyzed cyclization of aldehydes with NH4I as the sole nitrogen source
Liu, Qiang,Ren, Shuang,Xiao, Jiang
, p. 22230 - 22233 (2020/07/03)
An atom-efficient, straightforward method for the synthesis of 2,4,6-triaryl-1,3,5-triazinesviairon-catalyzed cyclization of aldehydes with NH4I as the sole nitrogen source is demonstrated. This strategy works smoothly under air atmosphere, and affords symmetrical 2,4,6-trisubstituted and unsymmetrical 1,3,5-triazines with yields from 18% to 72%. Compared to other methods, the present protocol provides a straightforward and atom-efficient approach to 2,4,6-trisubstituted 1,3,5-triazines using an inexpensive, easily available ammonium salt as the sole nitrogen source. Research into the preliminary mechanism indicates thatN-benzylidenebenzimidamides are involved in this cyclization reaction.
Reactions of bis(silyl-substituted) methyllithium with α-hydrogen- free nitriles into 1,3,5-triazines
Chen, Xia,Bai, Sheng-Di,Wang, Li,Liu, Dian-Sheng
, p. 1425 - 1430 (2007/10/03)
Bis(silyl-substituted) methyllithium has been found to catalyze a conversion of α-hydrogen-free nitriles directly to yield 2,4,6-trisubsituted s-triazines. The generally high yields and relatively mild reaction conditions of this procedure suggest an alternative to other aromatic nitrile cyclotrimerization reactions. Silicotropic rearrangements from C to N or N to N and an unusual elimination of LiCR2R (R=SiMe3, R=SiMe2NMe2) were observed.
Synthesis of nitrile oligomers through multiple anion capture reactions of allene dianions
Langer, Peter,Doering, Manfred,Seyferth, Dietmar,Goerls, Helmar
, p. 1948 - 1953 (2007/10/03)
Domino reactions between 1,1-dilithio-3,3-diphenylallene and nitriles resulted in the formation of products containing up to four nitrile molecules, representing the highest number to date of nitrile molecules involved in the formation of unambiguously ch
Lanthanide(III) Ion Catalyzed Reaction of Ammonia and Nitriles: Synthesis of 2,4,6-Trisubstituted-s-triazines
Forsberg, John H.,Spaziano, Vincent T.,Klump, Stephen P.,Sanders, Kathleen M.
, p. 767 - 770 (2007/10/02)
Lanthanum and yttrium trifluoromethanesulfonates at 1 mole percent concentration, have been found to catalyze a reaction between ammonia and aromatic nitriles to yield symmetrically substituted 2,4,6-triaryl-s-triazines.The generally high yields and relatively mild reaction conditions of this procedure suggest it as an alternative to other aromatic nitrile cyclotrimerization reactions.Of the aliphatic nitriles studied, acetonitrile and cyclopropanecarbonitrile gave good yields of triazine, propionitrile and butyronitrile gave significantly reduced yields of triazines 3b and3c respectively.Rearrangement of 3a and 3b to alkylated-4-aminopyrimidines was observed.
Preparation of sym-triazines by trimerization of nitriles in trifluoromethanesulfonic acid
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, (2008/06/13)
Aliphatic and aromatic nitriles are trimerized to substituted symmetrical triazines in the presence of trifluoromethanesulfonic acid.
