4068-53-5Relevant academic research and scientific papers
Synthesis of Cyclic Peptide Mimetics by the Successive Ring Expansion of Lactams
Stephens, Thomas C.,Lodi, Mahendar,Steer, Andrew M.,Lin, Yun,Gill, Matthew T.,Unsworth, William P.
, p. 13314 - 13318 (2017)
A successive ring-expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution. This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.
Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Stephens, Thomas C.,Lawer, Aggie,French, Thomas,Unsworth, William P.
, p. 13947 - 13953 (2018/09/14)
Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise
