4068-57-9Relevant academic research and scientific papers
(Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors
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Page/Page column 25; 26, (2010/02/11)
The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.
Process for preparing dibenzofurans via catalytic heteroannulation
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, (2008/06/13)
The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxylic acid by a stereospecific catalytic heteroannulation synthesis free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydr
Process for preparing chiral dibenzofurans via intramolecular heck reaction
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, (2008/06/13)
The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxylic acid by an intramolecular Heck stereospecific synthesis substantially free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-t
Kinetics and Mechanism of Iodination of Disubstituted-phenols in Aqueous Acetic Acid
Vibhute, Y. B.,Dasharath, D.
, p. 835 - 837 (2007/10/02)
Kinetics of iodination of 2,4-dinitro-, 2,4-dichloro- and 2,4-dibromophenols and 5-sulpho- and 5-chlorosalicylic acids by iodine monochloride in (70 : 30percent, v/v) acetic acid and water mixture medium, have been studied.The overall order is two in all
