40681-65-0

Upstream product

• 694-80-4 2-bromo-1-chlorobenzene 
• 51-90-1 [14C]carbon dioxide 
• 615-41-8 2-iodochlorobenzene 
• 1882-53-7 barium [14-C]carbonate 
• 62-53-3 aniline 

Downstream Products

• 67120-96-1 [1-¹⁴C]-o-chlorobenzyl alcohol 
• 67120-95-0 o-chlorobenz[¹⁴C]aldehyde 
• 67297-65-8 [1-¹⁴C]-o-chlorobenzylidenemalononitrile 
• 1604842-10-5 [methylene-14C]ticlopidine hydrochloride 
• 1604842-11-6 [methylene-14C]ticlopidine 

Relevant academic research and scientific papers

A short expedient synthesis of [14C]Ticlopidine

To support the development of a reactive metabolite strategy, the preparation of several radiolabelled compounds such as [14C] Ticlopidine was required. In this report, we describe a facile and rapid synthesis of [14C] Ticlopidine starting from [14C] carbon dioxide. The compound was radiolabelled in the 2-chloromethyl portion of the molecule with a specific activity of 53.4 mCi/mmol and with a radiochemical purity of 98.5%. Storage stability was best as the hydrochloride salt in an ethanol solution. Copyright

The synthesis of [3H] and [14C]o- chlorobenzylidenemalononitrile (CS)

Using similar procedures, the syntheses of [2-14C]-malononitrile and malono [14C]nitrile are described. Condensation with o-chlorobenzaldehyde affords [2-14C]-o-chlorobenzylidenemalononitrile and o-chlorobenzylidenemalono [14C]nitrile respectively. The syntheses of [3H]o-chlorobenzaldehyde and o-chlorobenz[ 14C]aldehyde, again by a common sequence of reactions, is described and with malononitrile gives [3H]-o-chlorobenzylidenemalononitrile and [1-14C]-o-chlorobenzylidenemalononitrile.