40681-65-0Relevant articles and documents
A short expedient synthesis of [14C]Ticlopidine
Hickey, Michael J.,Kingston, Lee P.,Allen, Paul H.,Johnson, Tim,Wilkinson, David J.
, p. 172 - 174 (2014)
To support the development of a reactive metabolite strategy, the preparation of several radiolabelled compounds such as [14C] Ticlopidine was required. In this report, we describe a facile and rapid synthesis of [14C] Ticlopidine starting from [14C] carbon dioxide. The compound was radiolabelled in the 2-chloromethyl portion of the molecule with a specific activity of 53.4 mCi/mmol and with a radiochemical purity of 98.5%. Storage stability was best as the hydrochloride salt in an ethanol solution. Copyright