40685-11-8

Upstream product

• 826-73-3 1-Benzosuberone 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 135274-44-1 6-[1-(Benzyl-methyl-amino)-meth-(E)-ylidene]-6,7,8,9-tetrahydro-benzocyclohepten-5-one 
• 35150-49-3 2-[4-methylphenylhydrazono]-1-benzosuberone 
• 54022-80-9 2-[4-chlorophenylhydrazono]-1-benzosuberone 
• 54022-81-0 2-(4-nitrophenylhydrazono)-1-benzosuberone 
• 35150-48-2 2-phenylhydrazono-1-benzosuberone 
• 135274-50-9 4-Dibenzylamino-3-phenyl-6,7-dihydro-5H-1-oxa-dibenzo[a,c]cyclohepten-2-one 
• 135274-55-4 3-Phenyl-4-(4-phenyl-piperazin-1-yl)-6,7-dihydro-5H-1-oxa-dibenzo[a,c]cyclohepten-2-one 
• 135274-54-3 4-(4-Methyl-piperazin-1-yl)-3-phenyl-6,7-dihydro-5H-1-oxa-dibenzo[a,c]cyclohepten-2-one 
• 135274-49-6 4-(Benzyl-methyl-amino)-3-phenyl-6,7-dihydro-5H-1-oxa-dibenzo[a,c]cyclohepten-2-one 
• 135274-48-5 4-Dimethylamino-3-phenyl-6,7-dihydro-5H-1-oxa-dibenzo[a,c]cyclohepten-2-one 
• 35150-50-6 Benzocyclohepten-5,6-dion-6-(4-brom-phenylhydrazon) 
• 135274-45-2 6-[1-Dibenzylamino-meth-(E)-ylidene]-6,7,8,9-tetrahydro-benzocyclohepten-5-one 
• 135274-47-4 6-[1-(4-Phenyl-piperazin-1-yl)-meth-(E)-ylidene]-6,7,8,9-tetrahydro-benzocyclohepten-5-one 

Relevant academic research and scientific papers

Asymmetric Transfer Hydrogenation of α-Substituted-β-Keto Carbonitriles via Dynamic Kinetic Resolution

A catalytic protocol for the enantio- and diastereoselective reduction of α-substituted-β-keto carbonitriles is described. The reaction involves a DKR-ATH process with the simultaneous construction of β-hydroxy carbonitrile scaffolds with two contiguous stereogenic centers. A wide range of α-substituted-β-keto carbonitriles were obtained in high yields (94%-98%) and excellent enantio- and diastereoselectivities (up to >99% ee, up to >99:1 dr). The origin of the diastereoselectivity was also rationalized by DFT calculations. Furthermore, this methodology offers rapid access to the pharmaceutical intermediates of Ipenoxazone and Tapentadol.

Synthesis of 1-Hydroxy-2-(hydroxy/hydroxymethyl)benzosuberans as Potential Biodynamic Agents

Hydrogenation of 2-hydroxymethylenebenzosuber-1-one (3), prepared by formylation of benzosuber-1-one (1), gives 2-hydroxymethylbenzosuberan (6) whereas KBH4 reduction of 3 affords 1,2-cis-1-hydroxy-2-hydroxymethylbenzosuberan (4). 1,2-cis-1,2-Dihydroxyben

Synthesis and Study of the Potential Antiallergic Activity of Some Pyrazole Derivatives

The synthesis and study of the oral antiallergic activity of a series of monopyrazole derivatives (2-14) considered as analogues of active bispyrazole 1 are described.None of the compounds showed significant inhibition of the rat passive cutaneous anaphylaxis (PCA), with the exception of the already known 5-aminoindazole (2).The activity of this compound is, however, lower than that of compound 1.