40692-28-2

Basic information

• Product Name: 2,3-diphenylpropan-1-aminium chloride
• Synonyms: 2,3-Diphenylpropan-1-amine hydrochloride (1:1); benzenepropanamine, beta-phenyl-, hydrochloride (1:1)
• CAS NO: 40692-28-2
• Molecular Formula: C₁₅H₁₇N*ClH
• Molecular Weight: 247.7631
• Mol File: 40692-28-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 315.5°C at 760 mmHg
• Flash Point: 144.2°C
• Vapor Pressure: 0.000437mmHg at 25°C
• CAS DataBase Reference: 2,3-diphenylpropan-1-aminium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenylpropan-1-aminium chloride(40692-28-2)
• EPA Substance Registry System: 2,3-diphenylpropan-1-aminium chloride(40692-28-2)

Safety Data

• Hazardous Substances Data: 40692-28-2(Hazardous Substances Data)

Usage

General Description

2,3-diphenylpropan-1-aminium chloride, also known as benzatropine, is a chemical compound with the molecular formula C20H24ClN. It is a quaternary ammonium compound that acts as a specific and potent inhibitor of the muscarinic acetylcholine receptors. This makes it useful as an anticholinergic agent, particularly in the treatment of Parkinson's disease and other movement disorders. Benzatropine is also known for its potential to induce euphoria and is sometimes abused as a recreational drug. It is available in both oral and injectable forms and is classified as a prescription medication due to its potential for abuse and dependence.

Upstream product

• 78515-43-2 2,3-Diphenylpropionaldehyde Oxime 
• 2510-95-4 2,3-diphenylacrylonitrile 
• 2016-03-7 2,3-diphenylpropanal 

Downstream Products

• 78515-44-3 2,3-Diphenyl-1-benzenesulfonamidopropane 

Relevant articles and documents

Reaction Pathway for the Formation of 3,3-Diphenyl-1-benzenesulfonamidopropane in the Aluminum Chloride Catalyst Reaction of 1-Benzenesulfonyl-2-(bromomethyl)ethylenimine and Benzene

The Friedel-Crafts reaction of 1-benzenesulfonyl-2-(bromomethyl)ethylenimine-2-(14)C and benzene yields 3,3-diphenyl-1-benzenesulfonamidopropane-2-(14)C.This finding, coupled with the results of an earlier tracer study, shows that the order of atoms in the three-carbon chain of the starting etylenimine persists unchanged in the product.If so, a previously suggested pathway becomes unacceptable.Of the several test compounds exposed to the action of aluminum chloride and benzene as described in the present work, only 1-benzenesulfonyl-2-benzylethylenimine and 1-benzenesulfonyl-2-phenylazetidine gave 3,3-diphenyl-1-benzenesulfonamidopropane.Since the azetidine compound could be eliminated as an intermediate in the ethylenimine process, this left only the benzyl derivative as an eligible intermediate.These data led to a revised pathway, which accommodates all the facts.An early stage in the mechanism is taken as conversion of the ethylenimine starting material to 1-benzenesulfonyl-2-benzylethylenimine.Under the reaction conditions, the latter compound generates a carbocationoid center on the middle carbon atom of its three-carbon chain.By a 1,2 hydride shift, this carbocation rearranges to the more stable benzylic carbocation, which combines with benzene to form the final product.