406937-90-4

Upstream product

• 1220-80-0 (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid 
• 130748-67-3 (2S)-N-(4-methylbenzene)-1-sulfonoamido-4-methylpentan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 61-90-5 L-leucine 
• 872-31-1 3-Bromothiophene 
• 124575-31-1 (S)-2-isobutyl-1-tosyl-aziridine 

Relevant academic research and scientific papers

A new convenient approach to chiral β-aryl(heteroaryl)alkylamines

Chiral β-aryl(heteroaryl)alkylamines have been prepared from N-tosyl alkylaziridines via regiospecific nucleophilic ring opening and subsequent desulfonylation in good to excellent yields. The corresponding aziridines are easily obtained from commercially available (S)-α-amino acids, so this method is the first effective route to asymmetric β-aryl(heteroaryl)alkylamines.