406937-99-3

Upstream product

• 139192-48-6 (S)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 72-18-4 L-valine 
• 17360-25-7 N-(p-toluenesulfonyl)-L-valine 
• 1003-09-4 2-bromothiophene 
• 62596-65-0 (2S)-2-isopropyl-1-[(4-methylphenyl)sulfonyl]aziridine 

Relevant academic research and scientific papers

A new convenient approach to chiral β-aryl(heteroaryl)alkylamines

Chiral β-aryl(heteroaryl)alkylamines have been prepared from N-tosyl alkylaziridines via regiospecific nucleophilic ring opening and subsequent desulfonylation in good to excellent yields. The corresponding aziridines are easily obtained from commercially available (S)-α-amino acids, so this method is the first effective route to asymmetric β-aryl(heteroaryl)alkylamines.