406938-39-4Relevant articles and documents
Alternative synthesis of tadalafil: PDE5 inhibitor
Anumula, Raghupathi Reddy,Madivada, Lokeswara Rao,Gilla, Goverdhan,Raju, V. V. N. K. Prasad,Kagga, Mukkanti,Reddy, Padi Pratap,Bhattacharya, Apurba,Bandichhor, Rakeshwar
, p. 4265 - 4271 (2008)
Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet-Spengeler type reaction and DCC (N,N′- dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)-mediated double amidation employing sarcosine ethyl ester hydrochlor
Method for synthesizing tadalafil
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Paragraph 0011; 0016, (2019/10/02)
The invention discloses a method for synthesizing tadalafil. Tadalafil is synthesized from D-tryptophan and a compound of formula 1. The method for preparing tadalafil of the invention can effectivelyprepare tadalafil. In addition, the starting material piperonyl dimethyl acetal of the preparation method is easy to obtain as a non-controlled material, the procurement and management are not restricted, the use of the controlled material piperonyl is effectively avoided, the management and procurement are convenient, the process steps are short, the production cost is greatly reduced, and the preparation method is more suitable for large-scale and industrial production of tadalafil.
Chemical compounds
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Page/Page column 11; 12, (2008/06/13)
Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.