407-96-5Relevant academic research and scientific papers
Preparation of 1,1-difluoroalkanes from aldehydes via 1,1-bistriflates: Advantageous use of HF-Lewis base reagents
Dolbier, William R.,Okamoto, Masamune
, p. 96 - 100 (2015/03/05)
Alkane-1,1-bistriflates, prepared in excellent yields by reaction of aldehydes with triflic anhydride, are converted to their respective 1,1-difluoroalkanes in good to excellent yield through reaction with fluorinating agent, triethylaminetrishydrofluorid
Use of Polyethylene Glycol in the Synthesis of Alkyl Fluorides from Alkyl Sulfonates
Badone, Domenico,Jommi, Giancarlo,Pagliarin, Roberto,Tavecchia, Paolo
, p. 920 - 921 (2007/10/02)
In the synthesis of monofluorinated organic compounds, the reaction of potassium fluoride with mesylates and tosylates of alcohols affords fluoro derivatives when polyethylene glycol 400 is used as solvent and catalyst.The limitation of this reaction is the solvolysis of the leaving group by the solvent; the phenomenon is controlled by the degree of steric hindrance around the reaction centre.
FLUORIERUNGSEIGENSCHAFTEN VON WF6
Haas, A.,Maciej, Th.
, p. 581 - 588 (2007/10/02)
WF6 reacts with aliphatic carbonyl- or carboxyl derivates to form the corresponding difluorides or carbonic acid fluorides.Fluorination of carbonyl compounds makes the presence of a Lewis acid like BF3 necessary.Trifluoromethyl compounds are not available in this way.Selective fluorination of alcoholes with WF6 is not possible.
