4070-43-3

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Ethyl hydrogen L-aspartate is used as a building block for the synthesis of new pharmaceuticals. Its unique chemical properties, derived from the ethyl group addition, make it a valuable component in the development of novel drug candidates.
Used in Biochemical Research:
In the field of biochemistry, 4-ethyl hydrogen L-aspartate serves as a useful tool for studying the structure, function, and interactions of aspartic acid and related compounds. This can aid in understanding the roles of amino acids in biological systems and contribute to the advancement of biochemical knowledge.
Used in Medicinal Chemistry:
4-Ethyl hydrogen L-aspartate holds potential in medicinal chemistry for the design and development of new therapeutic agents. Its synthetic nature and modified properties may lead to the creation of drugs with improved efficacy, selectivity, or reduced side effects compared to existing treatments.

InChI:InChI=1/C6H11NO4/c1-2-11-6(10)4(7)3-5(8)9/h4H,2-3,7H2,1H3,(H,8,9)/t4-/m0/s1

Upstream product

• 64-17-5 ethanol 
• 56-84-8 L-Aspartic acid 
• 123098-60-2 (3S,5R,6S)-3-Ethoxycarbonylmethyl-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester 

Downstream Products

• 7195-20-2 N-Ethyl-L-asparagin 
• 7175-34-0 Asn-NH-CH₃ 
• 70-47-3 L-asparagine 

Relevant academic research and scientific papers

Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues

The synthesis of xylose-bearing cyclic octalipopeptides burkholdine-1213 analogues is described. Sugar-containing lipopeptides are generally highly amphiphilic and often exhibit potent antifungal activities, but a synthesis of a xylose-bearing burkholdine analogue has never been reported. We prepared burkholdine-1213 analogues by solution-phase macrolactamization of xylose-bearing linear peptides obtained by incorporating the bespoke Fmoc-Ser(β-O-xyloseAc3)-OH building block into a Fmoc-solid phase peptide synthesis protocol. All analogues synthesized exhibited similar properties and moderate antifungal activities.

ASYMMETRIC SYNTHESIS OF α-AMINO ACIDS: COMPARISON OF ENOLATE VS. CATION FUNCTIONALIZATION OF N-BOC-5,6-DIPHENYL-2,3,5,6-TETRAHYDRO-4H-1,4-OXAZIN-2-ONES

Enolate generation and subsequent alkylation of the chiral glycinates 1 and 2 occurs with a high degree of diastereoselectivity.Reduction of the homologation products (3 and 4) furnishes with high enantiomeric excess, the N-t-BOC, and free α-amino acid derivates 5 and 6, respectively.

A Simple and Convenient Synthesis of β-Aspartates and γ-Glutamates

A simple and convenient, high yield synthesis of ω-esters of aspartic as well as glutamic acid has been developed, using tetrafluoroboric acid as catalyst. (13)C-NMR data of the products are given.