40716-66-3Relevant articles and documents
Yasuda et al.
, p. 2621 (1976)
Tuning the catalytic performance for the semi-hydrogenation of alkynols by selectively poisoning the active sites of Pd catalysts
Mao, Shanjun,Zhao, Bowen,Wang, Zhe,Gong, Yutong,Lü, Guofeng,Ma, Xiao,Yu, Lili,Wang, Yong
, p. 4143 - 4151 (2019/08/07)
Semi-hydrogenation of alkynols to alkenols with Pd-based catalysts is of great significance in fine chemical industries. Industrial Lindlar catalysts, employing Pb to modify the Pd nanoparticles for higher selectivity toward alkenols, however, generally suffer from both a severe activity decrease and environment pollution caused by using heavy metal Pb and additives. Therefore, how to overcome the selectivity-activity paradox remains a great challenge in industry. Here, we report a controllable strategy for the synthesis of semi-hydrogenation catalysts, which successfully improves the catalytic performance through selectively poisoning the edge and corner sites of Pd nanoparticles. When the integrity of the crystal face is reserved, both higher activity (～1340 h-1) and selectivity (～95% at 99% conversion) are achieved in the semi-hydrogenation of 2-methyl-3-butyn-2-ol (MBY) in ethanol, an industrially important intermediate product for the synthesis of vitamin E, without adding any toxic additives. What's more, the yield could exceed 98% at 99% conversion under no solvent and organic adsorbate conditions, which had never been achieved before. This work provides a different perspective to design and develop high performance catalysts for semi-hydrogenation of alkenols or even substituted alkynes.
Prenyl Praxis: A Method for Direct Photocatalytic Defluoroprenylation
Priya, Sonal,Weaver, Jimmie D.
supporting information, p. 16020 - 16025 (2018/11/27)
The prenyl fragment is the quintessential constituent of terpenoid natural products, a diverse family which contains numerous members with diverse biological properties. In contrast, fluorinated and multifluorinated arenes make up an important class of anthropogenic molecules which are highly relevant to material, agricultural, and pharmaceutical industries. While allylation chemistry is well developed, effective prenylation strategies have been less forthcoming. Herein, we describe the photocatalytic defluoroprenylation, a powerful method that provides access to "hybrid molecules" that possess both the functionality of a prenyl group and fluorinated arenes. This approach involves direct prenyl group transfer under very mild conditions, displays excellent functional group tolerance, and includes relatively short reaction times (4 h), which is the fastest photocatalytic C-F functionalization developed to date. Additionally, the strategy can be extended to include allyl and geranyl (10 carbon fragment) transfers. Another prominent finding is a reagent-dependent switch in regioselectivity of the major product from para to ortho C-F functionalization.
