40727-03-5

Upstream product

• 21076-09-5 2-methyl-4-phenyl-3-thiosemicarbazide 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 88305-54-8 Toluene-4-sulfonate3-(2,5-dihydroxy-3,4-dimethyl-phenylsulfanyl)-1,5-dimethyl-4-phenyl-4H-[1,2,4]triazol-1-ium; 

Relevant academic research and scientific papers

A Study of the Behaviour of 2,4-Substituted Thiosemicarbazides toward Orthoesters: Formation of Mesoionic Compounds

The reactions beetwen 2,4-disubstituted thiosemicarbazides and orthoesters in refluxing xylene led to the formation of the 1,2,4-triazoline-5-thione ring and to the 1,2,4-triazolium-5-thiolate ring. The formation of the mesoionic componds is due to rearrangement of the easily available 2,4-disubstituted thiosemicarbazides to 1,4-disubstituted thiosemicarbazides under the reaction conditions adopted. This method can be usefully used for the synthesis of mesoionic compounds, especially in the case of the 2-methyl-4-phenylthiosemicarbazide.