40732-91-0

Usage

Uses

Used in Organic Chemistry Research:
1,3-Dihydro-alpha-hydroxy-1,3-dioxo-2H-isoindole-2-butanoic acid is used as a research compound for exploring its chemical properties and potential applications in organic chemistry. Its unique structure and characteristics make it a valuable subject for scientific study and experimentation.
Used in Pharmaceutical Development:
Although its specific applications are still being researched, 1,3-Dihydro-alpha-hydroxy-1,3-dioxo-2H-isoindole-2-butanoic acid may be utilized as a building block or intermediate in the synthesis of pharmaceutical compounds. Its presence in the class of hydroxy isoindolines suggests that it could contribute to the development of new drugs or drug delivery systems.
Used in Material Science:
Given its chemical composition and properties, 1,3-Dihydro-alpha-hydroxy-1,3-dioxo-2H-isoindole-2-butanoic acid could potentially be employed in the development of new materials with specific characteristics, such as improved stability, reactivity, or other desirable traits. Its use in material science would depend on the outcomes of ongoing research and the discovery of its specific properties and interactions with other compounds.

Upstream product

• 35197-64-9 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid 
• 1074-82-4 potassium phtalimide 
• 19444-84-9 3-hydroxyoxolan-2-one 
• 85-44-9 phthalic anhydride 
• 13477-53-7 4-amino-2-hydroxybutyric acid 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 100061-16-3 3-hydroxy-1-(2-nitro-benzyl)-pyrrolidin-2-one 
• 3938-83-8 (S)-4-amino-2-hydroxybutanoic acid 
• 31771-40-1 (R)-β-hydroxy-4-aminobutyric acid 
• 37517-28-5 amikacin 

Relevant academic research and scientific papers

Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1–4 inhibitors

In this study, we report the synthesis and biological evaluation of a variety of α- and β-hydroxy substituted amino acid derivatives as potential amino acid subunits in inhibitors of GABA uptake transporters (GATs). In order to ensure that the test compounds adopt a binding pose similar to that presumed for related larger GAT inhibitors, lipophilic residues were introduced either at the amino nitrogen atom or at the alcohol function. Several of the synthesized compounds were found to exhibit similar inhibitory activity at the GAT subtypes mGAT2, mGAT3, and mGAT4, respectively, as compared with the reference N-butylnipecotic acid. Hence, these compounds might serve as starting point for future developments of more complex GAT inhibitors.

Synthesis method of amikacin intermediate

The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis method of an amikacin intermediate. Phthaloyl chloride and 2-hydroxy-4-aminobutyric acid serve as theinitial raw materials, an acid-binding agent and a catalyst are added, the process of heating, washing, recrystallizing and the like is adopted, and finally the target amikacin intermediate product (2-hydroxy-4-phthaloyl iminobutyric acid) is obtained. In the synthesis method, the raw materials are easy to obtain, less reagents participate in the reaction, the steps are simple, operation is convenient, reaction conditions are mind, the product yield is high, and the method is suitable for industrial large-scale production.

Synthesis method of gamma-phthalimido-alpha-hydroxybutyrate serving as methoxy kanamycin drug intermediate

A synthesis method of gamma-phthalimido-alpha-hydroxybutyrate serving as a methoxy kanamycin drug intermediate comprises steps as follows: 0.14-0.16 mol of phthalic anhydride, 0.12 mol of L-gamma-hydroxyamino-alpha-hydroxybutyrate and 80-90 ml of a cyclohexane solution are added to a reaction container provided with a distillation device, the stirring speed is controlled to be 110-130 rpm, the solution temperature is increased to 85-90 DEG C, the temperature of the solution is increased to 105-110 DEG C after 30-40 min, reduced pressure distillation is performed for 4-5 h, brown transparent melts are obtained, cooled and cured, and brown solids are obtained; the brown solids are added to 400 ml of a potassium chloride solution, the temperature of the solution is increased to 60-70 DEG C, molecular sieves are decolored, an oxalic acid solution is added until pH of the solution is 2-3, solids are separated out, subjected to suction filtration, washed with a saline solution, dewatered with a dewatering agent and recrystallized in acetonitrile, and gamma-phthalimido-alpha-hydroxybutyrate is obtained; the mass percentage of the cyclohexane solution is 80%-85%, and the pressure for reduced pressure distillation is 1.6-1.7 kPa.

Acid-mediated intramolecular cationic cyclization using an oxygen atom as internal nucleophile: Synthesis of substituted oxazolo-, oxazino- and oxazepinoisoindolinones

Efficient assembly of substituted oxazolo-, oxazino-, and oxazepinoisoindolinones (5-7, 12-15 and 19) is described in three steps according to an acidic α-oxoamidoalkylation reaction from ready available phthalic anhydride by successive imidation, sodium borohydride reduction and intramolecular cationic cyclization involving N-acyliminium species. The relative stereochemistry accompanying these reactions was also discussed.