4074-43-5

Usage

Uses

Used in Chemical Industry:
3-Butylphenol is used as an intermediate in the synthesis of various chemicals, such as antioxidants, plasticizers, and other additives. Its chemical properties make it a versatile building block for creating a range of products with specific applications in the chemical industry.
Used in Pharmaceutical Industry:
3-Butylphenol is utilized as a starting material for the production of pharmaceutical compounds, including drugs and drug intermediates. Its unique chemical structure allows for the development of new therapeutic agents with potential applications in the treatment of various medical conditions.
Used in Flavor and Fragrance Industry:
3-Butylphenol is employed as a component in the formulation of fragrances and flavors due to its distinct aromatic properties. It contributes to the overall scent and taste profile of various consumer products, such as perfumes, cosmetics, and the food industry.
Used in Dyes and Pigments Industry:
3-Butylphenol serves as a key ingredient in the production of dyes and pigments, particularly those used in the textile, paint, and coatings industries. Its chemical properties enable the creation of vibrant and stable colorants with a wide range of applications.
Used in Rubber Industry:
3-Butylphenol is used as an additive in the rubber industry to enhance the properties of rubber products, such as improving their resistance to oxidation, heat, and light. This results in improved durability and performance of rubber goods in various applications.

Potential Exposure

Butylphenols may be used as intermediates in manufacturing varnish and lacquer resins; as a germicidal agent in detergent disinfectants; as a pour point depressant, in motor-oil additives; de-emulsifier for oil; soap-antioxidant, plasticizer, fumigant, and insecticide

Shipping

UN2430 Alkylphenols, solid, n.o.s. (including C2-C12 homologues), Hazard class: 8; Labels: 8— Corrosive material

Incompatibilities

Vapors may form explosive mixture with air. These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may cause the gas to ignite and explode. Heat is also generated by the acid-base reaction with bases; such heating may initiate polymerization of the organic compound. React with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock

InChI:InChI=1/C10H14O/c1-2-3-5-9-6-4-7-10(11)8-9/h4,6-8,11H,2-3,5H2,1H3

Upstream product

• 103323-29-1 1-(3-hydroxy-phenyl)-butan-1-one 
• 109-72-8 n-butyllithium 
• 591-20-8 3-Bromophenol 
• 20893-43-0 1-butyl-3-methoxybenzene 
• 702660-55-7 1-(3-hydroxyphenyl)but-1-ene 
• 6301-49-1 3-butylcyclohexenone 

Downstream Products

• 1108607-44-8 di(2-n-butyl-4-hydroxyphenyl)sulphide 
• 107821-11-4 (2-ethyl-5-butyl-phenoxy)-acetic acid 
• 107821-37-4 (4-ethyl-3-butyl-phenoxy)-acetic acid 
• 105337-19-7 4'-butyl-2'-hydroxyacetophenone 
• 105337-80-2 1-(2-butyl-4-hydroxy-phenyl)-ethanone 
• 107055-23-2 4-ethyl-3-butyl-phenol 
• 72386-21-1 2-ethyl-5-n-butylphenol 
• 532966-06-6 2-hydroxy-4-n-butylbenzaldehyde 
• 60407-44-5 Propyl-carbamic acid 3-butyl-phenyl ester 
• 63834-63-9 3-(3-butyl-phenoxy)-propane-1,2-diol 
• 1878-53-1 (3-butyl-phenoxy)-acetic acid 

Relevant academic research and scientific papers

Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands

Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture. Both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60 °C) in air, and in competition with protonolysis. Additional benefits include very short reaction times (20 s), good to excellent yields (up to 98 %), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water.

Copper-catalyzed oxidative aromatization of 2-cyclohexen-1-ones to phenols in the presence of catalytic hydrogen bromide under molecular oxygen

Catalytic oxidative aromatization has been achieved using 2-cyclohexen-1-ones to obtain phenol derivatives in the presence of a catalytic amount of copper salt and aqueous HBr under molecular oxygen. The amount of HBr was successfully reduced to a catalytic quantity, and the other additive such as a ligand and an oxidant as well as inert conditions were unnecessary. Various mono-, di-, and trisubstituted phenols with substituents at the desired positions could be synthesized under cheap and simple conditions. An oxidative aromatization/bromination sequence was also demonstrated to obtain bromophenols with excess HBr. The Royal Society of Chemistry 2013.

A 'meta effect' in the fragmentation reactions of ionised alkyl phenols and alkyl anisoles

The competition between benzylic cleavage (simple bond fission [SBF]) and retro-ene rearrangement (RER) from ionised ortho, meta and para RC 6H4OH and RC6H4OCH3 (R = n-C3H7, n-C4H9, n-C5H11, n-C7H15, n-C9H19, n-C 15H31) is examined. It is observed that the SBF/RER ratio is significantly influenced by the position of the substituent on the aromatic ring. As a rule, phenols and anisoles substituted by an alkyl group in meta position lead to more abundant methylene-2,4-cyclohexadiene cations (RER fragmentation) than their ortho and para homologues. This 'meta effect' is explained on the basis of energetic and kinetic of the two reaction channels. Quantum chemistry computations have been used to provide estimate of the thermochemistry associated with these two fragmentation routes. G3B3 calculation shows that a hydroxy or a methoxy group in the meta position destabilises the SBF and stabilises the RER product ions. Modelling of the SBF/RER intensities ratio has been performed assuming two single reaction rates for both fragmentation processes and computing them within the statistical RRKM formalism in the case of ortho, meta and para butyl phenols. It is clearly demonstrated that, combining thermochemistry and kinetics, the inequality (SBF/RER) metaorthopara holds for the butyl phenols series. It is expected that the 'meta effect' described in this study enables unequivocal identification of meta isomers from ortho and para isomers not only of alkyl phenols and alkyl anisoles but also in other alkyl benzene series. Copyright

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

The separation and synthesis of lipidic 1,2- and 1,3-diols from natural phenolic lipids for the complexation and recovery of boron

A study has been made of the semi-synthesis of 1,3-diols (anacardic alcohols) from natural phenolic lipid resources from Anacardium occidentale and Anacardium giganteum which have given C15 and C11 derivatives, respectively. An isomeric 1,3-diol (isoanacardic alcohol) has been obtained from cardanol separated from technical cashew nut-shell liquid. Homologous1,3-diols have been synthesised from a range of synthetic 2-alkyl-, 3-alkyl- and 4-alkylphenols and from 6-alkylsalicylic acids. The natural 1,2-diol, urushiol, from Rhus vernicifera has been purified. All these lipidic compounds have been studied for their complexation and the potential recovery of boron as boric acid.