407587-33-1 Usage
Uses
Used in Pharmaceutical Industry:
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid is used as a building block for the synthesis of novel pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, such as modulating ion channels or targeting specific receptors.
Used in Chemical Research:
In the field of chemical research, 6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid serves as a valuable compound for studying its reactivity, stability, and potential interactions with other molecules. This can lead to a better understanding of its properties and the discovery of new chemical reactions or processes.
Used in Inhibitor Development:
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid is used as a potent, selective class A inhibitor of calcium-activated chloride channels (CaCCs). By targeting these channels, it can potentially be employed in the treatment of various conditions related to ion channel dysfunction, such as cystic fibrosis, chronic obstructive pulmonary disease (COPD), and certain neurological disorders.
Biochem/physiol Actions
CaCCinh-A01 is a TMEM16A (transmembrane member 16A) inhibitor. It also blocks anoctamin-1 (ANO1) and decreases cell viability and represses cell migration.
Check Digit Verification of cas no
The CAS Registry Mumber 407587-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,7,5,8 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 407587-33:
(8*4)+(7*0)+(6*7)+(5*5)+(4*8)+(3*7)+(2*3)+(1*3)=161
161 % 10 = 1
So 407587-33-1 is a valid CAS Registry Number.
407587-33-1Relevant academic research and scientific papers
Inhibitors of calcium-activated chloride channels
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, (2017/11/07)
Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride th
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
De La Fuente, Ricardo,Namkung, Wan,Mills, Aaron,Verkman, Alan S.
, p. 758 - 768 (2008/09/20)
Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues, including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC inhibitors have not been available. We established a high-throughput scree
