407631-13-4

Upstream product

• 407630-93-7 O-methyl N-[1-(4-methoxybenzyl)-2-chloroindol-3-ylcarbonyl]thiocarbamate 
• 77655-47-1 1-(p-metossibenzil)-2-cloroindol-3-carbossialdeide 
• 407630-87-9 2-chloro-1-(4-methoxy-benzyl)-1H-indole-3-carbonyl chloride 
• 407630-85-7 1-(4-methoxybenzyl)-2-chloroindole-3-carboxylic acid 
• 407630-89-1 1-(4-methoxybenzyl)-2-chloroindol-3-ylcarbonyl isothiocyanate 

Relevant academic research and scientific papers

A new approach to the synthesis of rare thiazino[6,5-b]indol-4-one derivatives. First total synthesis of the indole phytoalexin cyclobrassinon

The first synthesis of the indole phytoalexin cyclobrassinon and some of its analogues, possessing a thiazino[6,5-b]indol-4-one tricyclic ring system was performed starting from 1-substitued 2-chloroindole-3-carboxaldehydes. The route employed the intramolecular Et3N-mediated or photochemical nucleophilic substitution of a chlorine atom in the 2-position of the indole ring with a sulfur atom as a key step. Examination of biological activity against the selected tumor cell lines, bacteria and fungi revealed no expressive activity of synthesized compounds.

A new photocyclization approach to the rare 1,3-thiazino[6,5-b]indol-4-one derivatives

The analogs of indole phytoalexin cyclobrassinon have been prepared in four steps from corresponding 1-substituted 2-chloroindole-3-carboxylic acids, employing a hitherto unknown photochemical cyclization of new indolyl thiocarbamates to 1,3-thiazino[6,5-b]indole-4-one derivatives as a key step.