40769-45-7Relevant academic research and scientific papers
Hydrolysis of 2'-Deoxypurine Nucleosides. The Effect of Substitution at the C-8 Position.
Laayoun, Ali,Decout, Jean-Luc,Lhomme, Jean
, p. 4989 - 4990 (2007/10/02)
The hydrolytic stability of 2'-deoxypurine nucleosides is decreased by introduction of electronwithdrawing substituents at the C-8 position in the series of compounds 2-8, 10-14.The sulfone group causes a 2.9 x 104 rate acceleration for glycosidic, bond cleavage in compound 14.
REACTION OF 5,6-DIAMINO-2-METHYLTHIO-4-PYRIMIDINONES WITH THIOUREA
Girshovich, M. Z.,Muravich-Aleksandr, Kh. L.,Ragozina, T.N.
, p. 2168 - 2171 (2007/10/02)
When 5,6-diamino-2-methylthio-4-pyrimidinones are fused with thiourea, 2-amino-8-mercapto-6-purinones (8-mercaptoguanines) are formed in addition to the expected 8-mercapto-2-methylthio-6-purinones (8-mercapto-2-methylthiohypoxanthines).If the reaction time is increased, only the 8-mercaptoguanines are formed.
