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2-AMINO-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL, also known as Alovudine, is a chemical compound with a pyrimidine base structure. It is a nucleoside reverse transcriptase inhibitor (NRTI) that has demonstrated antiviral activity against HIV and other retroviruses. Alovudine has been studied for its potential use in the treatment of HIV/AIDS, showing promising results in preclinical studies. However, its development has been discontinued due to safety concerns, particularly its association with mitochondrial toxicity and lactic acidosis. Despite these setbacks, the unique structure of 2-AMINO-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL makes it of interest for further research into potential antiviral drugs.

40775-79-9

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40775-79-9 Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL is used as a research compound for the development of antiviral drugs, specifically targeting HIV and other retroviruses. Its unique structure and antiviral activity make it a valuable candidate for further investigation and potential application in the treatment of HIV/AIDS.
However, due to safety concerns related to mitochondrial toxicity and lactic acidosis, its development as a therapeutic agent has been discontinued. Despite this, the compound's potential for future research and development in the field of antiviral drugs remains significant, as it may contribute to the discovery of new and safer treatments for viral infections.

Check Digit Verification of cas no

The CAS Registry Mumber 40775-79-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,7,7 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40775-79:
(7*4)+(6*0)+(5*7)+(4*7)+(3*5)+(2*7)+(1*9)=129
129 % 10 = 9
So 40775-79-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N5O/c1-3-2-4(12)11-6(8-3)9-5(7)10-11/h2H,1H3,(H3,7,8,9,10)

40775-79-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-AMINO-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL

1.2 Other means of identification

Product number -
Other names IFLAB-BB F1274-0263

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40775-79-9 SDS

40775-79-9Relevant academic research and scientific papers

SUBSTITUTED TRIAZOLO BICYCLICCOMPOUNDS AS PDE2 INHIBITORS

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Page/Page column 181, (2017/01/23)

The present invention is directed to substituted triazolo bicycliccompounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also

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