40788-04-3

Basic information

• Product Name: 1-(1,1-Difluoroethyl)-3-nitrobenzene
• Synonyms: 1-(1,1-Difluoroethyl)-3-nitrobenzene
• CAS NO: 40788-04-3
• Molecular Formula: C₈H₇F₂NO₂
• Molecular Weight: 187.1434864
• Mol File: 40788-04-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(1,1-Difluoroethyl)-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,1-Difluoroethyl)-3-nitrobenzene(40788-04-3)
• EPA Substance Registry System: 1-(1,1-Difluoroethyl)-3-nitrobenzene(40788-04-3)

Safety Data

• Hazardous Substances Data: 40788-04-3(Hazardous Substances Data)

Usage

General Description

1-(1,1-Difluoroethyl)-3-nitrobenzene is a chemical compound with the molecular formula C8H6F2NO2. It is a nitrobenzene derivative with a 1,1-difluoroethyl group attached to the benzene ring. 1-(1,1-Difluoroethyl)-3-nitrobenzene is used in organic synthesis and can be employed as an intermediate in the production of pharmaceuticals, pesticides, and other fine chemicals. It is also a potentially hazardous chemical and should be handled with care and according to the appropriate safety protocols.

Upstream product

• 72278-09-2 (E)-1-(3-mitrophenyl)ethan-1-one O-methyl oxime 
• 121-89-1 3-Nitroacetophenone 

Downstream Products

• 1000044-18-7 1-[3-(1,1-difluoroethyl)phenyl]piperazine hydrochloride 
• 40788-05-4 3-(1,1-difluoroethyl)aniline 

Relevant articles and documents

Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)

A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

Tricyclic Compounds As mPGES-1 Inhibitors

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.