40800-70-2

Upstream product

• 22551-24-2 2-(methylthio)acetamide 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 54523-76-1 4-aminoindolin-2-one 
• 1474049-06-3 4-methoxy-N-(2-oxoindolin-4-ylcarbamoyl)benzamide 
• 1474049-07-4 (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-ylcarbamoyl)-4-methoxybenzamide 
• 1474049-94-9 (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1474049-93-8 1-(4-fluorophenyl)-2-oxo-N-(2-oxoindolin-4-yl)-1,2-dihydropyridine-3-carboxamide 

Relevant academic research and scientific papers

N-Chlorophthalimide as a mild and efficient chlorination reagent in the Gassman ortho alkylation of aromatic amines. Synthesis of 3-(methylthio)oxindoles

A practical modification of the Gassman 3-(methylthio)oxindole synthesis is reported. In our method, substituted anilines and 2-(methylthio)acetamide were reacted under mild reaction conditions, in the presence of N-chlorophthalimide as a chlorinating agent to give α-amidosulfides, which, in the next step of the process, were cyclized to give 3-(methylthio)oxindoles. The method was successfully applied for the synthesis of the key intermediate, 2-(2-amino-3-benzoylphenyl)-2-(methylthio)acetamide, in the process of the preparation of nepafenac, a commonly used ophthalmic drug.