408308-26-9

Basic information

• Product Name: 4-(methyl(phenyl)amino)-2-methylene-4-oxobutanoic acid
• Synonyms: 4-(methyl(phenyl)amino)-2-methylene-4-oxobutanoic acid
• CAS NO: 408308-26-9
• Molecular Weight: 219.24
• Mol File: 408308-26-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(methyl(phenyl)amino)-2-methylene-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methyl(phenyl)amino)-2-methylene-4-oxobutanoic acid(408308-26-9)
• EPA Substance Registry System: 4-(methyl(phenyl)amino)-2-methylene-4-oxobutanoic acid(408308-26-9)

Safety Data

• Hazardous Substances Data: 408308-26-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 2170-03-8 itaconic acid anhydride 
• 100-61-8 N-methylaniline 

Downstream Products

• 1015076-69-3 C₁₄H₁₇N₃O₃ 

Relevant articles and documents

Biobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals

Spiroimides exhibit a wide range of biological activities, such as anticonvulsant, antiarrhythmic, and antihyperglycemic activities. Herein, a novel synthetic application of renewable chemicals, itaconic acid and formamides, is described. Proper exploitation of the reactivity of itaconic acid and formamide allows for the development of an efficient synthetic approach for the production of several new biobased spiroimides, spiro[dihydroquinolin-2-one-succinimides] and spiro[indolin-2-one-glutarimides], in excellent overall yields (up to 98%).

SYNTHESIS OF LEUKOTRIENE COMPOUNDS

The present invention relates to the synthesis of leukotriene receptor agonist compounds and to novel intermediates employed in their preparation. Leukotriene agonists are used in the treatment of asthma, as well as other conditions mediated by leukotrienes such as inflammation and allergies. A compound of particular interest is montelukast and the present invention describes an improved process for making montelukast and similar compounds.