408316-13-2Relevant academic research and scientific papers
Synthesis of α,α-disubstituted β-amino esters and peptide derivatives
Alonso,Del Pozo,Gonza?lez
, p. 69 - 72 (2002)
The synthesis of α,α-disubstituted β-amino esters and peptide derivatives from readily available 4-spiro-β-lactams 1 is described. The geminally disubstituted β-amino esters are obtained from the N-Boc spiro β-lactams 2 by treatment with potassium cyanide in methanol. Alternatively, the use of spiro β-lactams 2 as acylating agents of the amino group of C-protected amino acids, allowed its direct incorporation into a peptidic chain.
